Changes in body composition in men and women with advanced nonsmall cell lung cancer (NSCLC) undergoing chemotherapy.

2.50
Hdl Handle:
http://hdl.handle.net/10541/107471
Title:
Changes in body composition in men and women with advanced nonsmall cell lung cancer (NSCLC) undergoing chemotherapy.
Authors:
Harvie, Michelle N; Campbell, I T; Thatcher, Nick; Baildam, Andrew D
Abstract:
BACKGROUND: Men with nonsmall cell lung cancer (NSCLC) are more susceptible to weight loss than women. The composition and aetiology of these gender specific weight changes are not known. METHODS: Measurements of body mass, body composition and energy balance (resting energy expenditure and energy intake) were made in 15 men and six women before and after chemotherapy for NSCLC. RESULTS: Over the course of chemotherapy minimal weight change was observed in both men and women. Men increased body fat from 25.0 +/- 5.5 to 27.9 +/- 7.9% (P < 0.05) whereas fat free mass (FFM) tended to decrease (P = 0.063). There was no change in body fat or FFM in the women. In the men resting energy expenditure decreased over the course of chemotherapy from 113.2 +/- 15.9 to 105.1 +/- 10.1% of the value predicted from the Harris Benedict equation (P < 0.05). In the women resting energy expenditure (REE) did not alter. CONCLUSION: Over the course of chemotherapy for NSCLC, men and women appear to have different patterns of change in body composition and in energy expenditure.
Affiliation:
University Departments of Anaesthesia Medical Oncology Surgery, South Manchester University Hospitals NHS Trust, Manchester M20 2LR, UK. m_harvie@fs1.with.man.ac.uk
Citation:
Changes in body composition in men and women with advanced nonsmall cell lung cancer (NSCLC) undergoing chemotherapy. 2003, 16 (5):323-6 J Hum Nutr Diet
Journal:
Journal of human nutrition and dietetics : the official journal of the British Dietetic Association
Issue Date:
Oct-2003
URI:
http://hdl.handle.net/10541/107471
PubMed ID:
14516379
Type:
Article
Language:
en
ISSN:
0952-3871
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorHarvie, Michelle Nen
dc.contributor.authorCampbell, I Ten
dc.contributor.authorThatcher, Nicken
dc.contributor.authorBaildam, Andrew Den
dc.date.accessioned2010-07-12T15:43:25Z-
dc.date.available2010-07-12T15:43:25Z-
dc.date.issued2003-10-
dc.identifier.citationChanges in body composition in men and women with advanced nonsmall cell lung cancer (NSCLC) undergoing chemotherapy. 2003, 16 (5):323-6 J Hum Nutr Dieten
dc.identifier.issn0952-3871-
dc.identifier.pmid14516379-
dc.identifier.urihttp://hdl.handle.net/10541/107471-
dc.description.abstractBACKGROUND: Men with nonsmall cell lung cancer (NSCLC) are more susceptible to weight loss than women. The composition and aetiology of these gender specific weight changes are not known. METHODS: Measurements of body mass, body composition and energy balance (resting energy expenditure and energy intake) were made in 15 men and six women before and after chemotherapy for NSCLC. RESULTS: Over the course of chemotherapy minimal weight change was observed in both men and women. Men increased body fat from 25.0 +/- 5.5 to 27.9 +/- 7.9% (P < 0.05) whereas fat free mass (FFM) tended to decrease (P = 0.063). There was no change in body fat or FFM in the women. In the men resting energy expenditure decreased over the course of chemotherapy from 113.2 +/- 15.9 to 105.1 +/- 10.1% of the value predicted from the Harris Benedict equation (P < 0.05). In the women resting energy expenditure (REE) did not alter. CONCLUSION: Over the course of chemotherapy for NSCLC, men and women appear to have different patterns of change in body composition and in energy expenditure.en
dc.language.isoenen
dc.subjectLung Canceren
dc.subject.meshAdipose Tissue-
dc.subject.meshAntineoplastic Agents-
dc.subject.meshBody Composition-
dc.subject.meshCarcinoma, Non-Small-Cell Lung-
dc.subject.meshEnergy Intake-
dc.subject.meshEnergy Metabolism-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshLung Neoplasms-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshMuscle, Skeletal-
dc.subject.meshProspective Studies-
dc.subject.meshSex Factors-
dc.titleChanges in body composition in men and women with advanced nonsmall cell lung cancer (NSCLC) undergoing chemotherapy.en
dc.typeArticleen
dc.contributor.departmentUniversity Departments of Anaesthesia Medical Oncology Surgery, South Manchester University Hospitals NHS Trust, Manchester M20 2LR, UK. m_harvie@fs1.with.man.ac.uken
dc.identifier.journalJournal of human nutrition and dietetics : the official journal of the British Dietetic Associationen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.