2.50
Hdl Handle:
http://hdl.handle.net/10541/107105
Title:
Episodic ACTH and cortisol secretion in normal children.
Authors:
Wallace, W Hamish B; Crowne, Elizabeth C; Shalet, Stephen M; Moore, C; Gibson, S; Littley, M D; White, A
Abstract:
The aim of this study was to determine the normal relationship between ACTH and cortisol secretion in children. Fourteen children (nine male, five female; median age 11.3 years) were hospitalized and blood samples were taken every 20 min for 24 h. A circadian rhythm was observed with median 0900 h and midnight ACTH values of 1.80 and less than 0.97 pmol/l, and for cortisol 296 and 62 nmol/l respectively. The median (range) areas under the curve for ACTH and cortisol were 29.7 (9.0-53.8) pmol/l/h and 5114 (3562-8630) nmol/l/h respectively. There were no significant differences detected for ACTH and cortisol secretion between males and females, or between prepubertal (n = 9) and pubertal subjects (n = 5). Using a novel form of time series analysis we have shown that both ACTH and cortisol are secreted with a dominant periodicity of 0.7-1.0 h, representing 24-34 secretory episodes of ACTH and cortisol in 24 h. For cortisol, but not ACTH, there is a significant secondary periodicity of 2-3.2 h. To look for shared periodicities we have used the technique of coherency. This reveals that for six of the children ACTH and cortisol are secreted with a significant shared periodicity of 0.8-1.0 h, and for a further five children a similar secondary shared periodicity is present. Therefore in normal children ACTH and cortisol secretion are interdependent and episodic but are not influenced by either pubertal status or gender.
Affiliation:
Department of Endocrinology, Christie Hospital, Manchester, UK.
Citation:
Episodic ACTH and cortisol secretion in normal children. 1991, 34 (3):215-21 Clin. Endocrinol.
Journal:
Clinical Endocrinology
Issue Date:
Mar-1991
URI:
http://hdl.handle.net/10541/107105
DOI:
10.1111/j.1365-2265.1991.tb00297.x
PubMed ID:
1645237
Type:
Article
Language:
en
ISSN:
0300-0664
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorWallace, W Hamish Ben
dc.contributor.authorCrowne, Elizabeth Cen
dc.contributor.authorShalet, Stephen Men
dc.contributor.authorMoore, Cen
dc.contributor.authorGibson, Sen
dc.contributor.authorLittley, M Den
dc.contributor.authorWhite, Aen
dc.date.accessioned2010-07-02T16:11:04Z-
dc.date.available2010-07-02T16:11:04Z-
dc.date.issued1991-03-
dc.identifier.citationEpisodic ACTH and cortisol secretion in normal children. 1991, 34 (3):215-21 Clin. Endocrinol.en
dc.identifier.issn0300-0664-
dc.identifier.pmid1645237-
dc.identifier.doi10.1111/j.1365-2265.1991.tb00297.x-
dc.identifier.urihttp://hdl.handle.net/10541/107105-
dc.description.abstractThe aim of this study was to determine the normal relationship between ACTH and cortisol secretion in children. Fourteen children (nine male, five female; median age 11.3 years) were hospitalized and blood samples were taken every 20 min for 24 h. A circadian rhythm was observed with median 0900 h and midnight ACTH values of 1.80 and less than 0.97 pmol/l, and for cortisol 296 and 62 nmol/l respectively. The median (range) areas under the curve for ACTH and cortisol were 29.7 (9.0-53.8) pmol/l/h and 5114 (3562-8630) nmol/l/h respectively. There were no significant differences detected for ACTH and cortisol secretion between males and females, or between prepubertal (n = 9) and pubertal subjects (n = 5). Using a novel form of time series analysis we have shown that both ACTH and cortisol are secreted with a dominant periodicity of 0.7-1.0 h, representing 24-34 secretory episodes of ACTH and cortisol in 24 h. For cortisol, but not ACTH, there is a significant secondary periodicity of 2-3.2 h. To look for shared periodicities we have used the technique of coherency. This reveals that for six of the children ACTH and cortisol are secreted with a significant shared periodicity of 0.8-1.0 h, and for a further five children a similar secondary shared periodicity is present. Therefore in normal children ACTH and cortisol secretion are interdependent and episodic but are not influenced by either pubertal status or gender.en
dc.language.isoenen
dc.subject.meshAdolescent-
dc.subject.meshAdrenocorticotropic Hormone-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshCircadian Rhythm-
dc.subject.meshFemale-
dc.subject.meshFourier Analysis-
dc.subject.meshHumans-
dc.subject.meshHydrocortisone-
dc.subject.meshImmunoradiometric Assay-
dc.subject.meshMale-
dc.titleEpisodic ACTH and cortisol secretion in normal children.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, Christie Hospital, Manchester, UK.en
dc.identifier.journalClinical Endocrinologyen

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