2.50
Hdl Handle:
http://hdl.handle.net/10541/106580
Title:
The role of MHC class I expression in developmental tumours.
Authors:
Stern, Peter L; Rinke de Wit, T F
Abstract:
Expression of HLA class I (-like) genes by two developmental tumour cell lines representing embryonic (Tera-2) and extra-embryonic (Jeg-3) origins is reviewed. The Tera-2 embryonal carcinoma cells are HLA negative but can be induced by gamma interferon to express HLA-A, -B, -C, and apparently -E and G genes. Jeg-3 choriocarcinoma cells constitutively express HLA-G and low levels of a novel HLA-C gene product. The NK sensitivity of the developmental tumour cell types has been assessed and the biochemical characteristics of the surface molecules expressed by the trophoblast derived cells has been further documented. The biological role of these novel HLA molecules in the context of the maternal acceptance of the fetal-semi-allograft is discussed.
Affiliation:
Department of Immunology, Paterson Institute for Cancer Research, Manchester, UK.
Citation:
The role of MHC class I expression in developmental tumours. 1991, 2 (1):11-6 Semin. Cancer Biol.
Journal:
Seminars in Cancer Biology
Issue Date:
Feb-1991
URI:
http://hdl.handle.net/10541/106580
PubMed ID:
1912513
Type:
Article
Language:
en
ISSN:
1044-579X
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorStern, Peter Len
dc.contributor.authorRinke de Wit, T Fen
dc.date.accessioned2010-06-21T14:03:06Z-
dc.date.available2010-06-21T14:03:06Z-
dc.date.issued1991-02-
dc.identifier.citationThe role of MHC class I expression in developmental tumours. 1991, 2 (1):11-6 Semin. Cancer Biol.en
dc.identifier.issn1044-579X-
dc.identifier.pmid1912513-
dc.identifier.urihttp://hdl.handle.net/10541/106580-
dc.description.abstractExpression of HLA class I (-like) genes by two developmental tumour cell lines representing embryonic (Tera-2) and extra-embryonic (Jeg-3) origins is reviewed. The Tera-2 embryonal carcinoma cells are HLA negative but can be induced by gamma interferon to express HLA-A, -B, -C, and apparently -E and G genes. Jeg-3 choriocarcinoma cells constitutively express HLA-G and low levels of a novel HLA-C gene product. The NK sensitivity of the developmental tumour cell types has been assessed and the biochemical characteristics of the surface molecules expressed by the trophoblast derived cells has been further documented. The biological role of these novel HLA molecules in the context of the maternal acceptance of the fetal-semi-allograft is discussed.en
dc.language.isoenen
dc.subject.meshAntibodies, Monoclonal-
dc.subject.meshBlotting, Northern-
dc.subject.meshCell Line-
dc.subject.meshChoriocarcinoma-
dc.subject.meshCytotoxicity, Immunologic-
dc.subject.meshGene Library-
dc.subject.meshHLA Antigens-
dc.subject.meshHLA-A Antigens-
dc.subject.meshHLA-B Antigens-
dc.subject.meshHLA-C Antigens-
dc.subject.meshHistocompatibility Antigens Class I-
dc.subject.meshHumans-
dc.subject.meshImmunophenotyping-
dc.subject.meshInterferon-gamma-
dc.subject.meshKiller Cells, Natural-
dc.subject.meshTeratoma-
dc.titleThe role of MHC class I expression in developmental tumours.en
dc.typeArticleen
dc.contributor.departmentDepartment of Immunology, Paterson Institute for Cancer Research, Manchester, UK.en
dc.identifier.journalSeminars in Cancer Biologyen

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