Medicinal plants in tropical medicine. 2. Natural products in cancer treatment from bench to the clinic.

2.50
Hdl Handle:
http://hdl.handle.net/10541/104755
Title:
Medicinal plants in tropical medicine. 2. Natural products in cancer treatment from bench to the clinic.
Authors:
Fox, Brian W
Abstract:
The development of anticancer agents has, in the past, relied heavily on leads derived from screening a wide variety of agents from both synthetic and natural sources. With the development of new techniques of measurement of biochemical changes in cells and the advent of molecular biological techniques, it is becoming clear that many naturally occurring agents, specifically selected for their tumour growth inhibiting activity, are highly complex and novel substances which are potentially promising as anticancer agents in the clinic. The process of getting a drug from the laboratory bench to the clinic is itself often complex due to adverse physical characteristics of the drug. The experience of the Cancer Research Campaign Clinical Trials Committee in developing several natural products, currently in various stages of development for clinical trial, is described. The drugs discussed include the vinca alkaloids, maytansine, combretastatins, bryostatin 1, pancratistatin, phyllanthoside, dolastatin 10, and taxol.
Affiliation:
Paterson Institute for Cancer Research, Christie Hospital, Withington, Manchester, UK.
Citation:
Medicinal plants in tropical medicine. 2. Natural products in cancer treatment from bench to the clinic., 85 (1):22-5 Trans. R. Soc. Trop. Med. Hyg.
Journal:
Transactions of the Royal Society of Tropical Medicine and Hygiene
Issue Date:
1991
URI:
http://hdl.handle.net/10541/104755
DOI:
10.1016/0035-9203(91)90140-T
PubMed ID:
2068749
Type:
Article
Language:
en
ISSN:
0035-9203
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorFox, Brian Wen
dc.date.accessioned2010-06-11T15:38:59Z-
dc.date.available2010-06-11T15:38:59Z-
dc.date.issued1991-
dc.identifier.citationMedicinal plants in tropical medicine. 2. Natural products in cancer treatment from bench to the clinic., 85 (1):22-5 Trans. R. Soc. Trop. Med. Hyg.en
dc.identifier.issn0035-9203-
dc.identifier.pmid2068749-
dc.identifier.doi10.1016/0035-9203(91)90140-T-
dc.identifier.urihttp://hdl.handle.net/10541/104755-
dc.description.abstractThe development of anticancer agents has, in the past, relied heavily on leads derived from screening a wide variety of agents from both synthetic and natural sources. With the development of new techniques of measurement of biochemical changes in cells and the advent of molecular biological techniques, it is becoming clear that many naturally occurring agents, specifically selected for their tumour growth inhibiting activity, are highly complex and novel substances which are potentially promising as anticancer agents in the clinic. The process of getting a drug from the laboratory bench to the clinic is itself often complex due to adverse physical characteristics of the drug. The experience of the Cancer Research Campaign Clinical Trials Committee in developing several natural products, currently in various stages of development for clinical trial, is described. The drugs discussed include the vinca alkaloids, maytansine, combretastatins, bryostatin 1, pancratistatin, phyllanthoside, dolastatin 10, and taxol.en
dc.language.isoenen
dc.subject.meshAntineoplastic Agents, Phytogenic-
dc.subject.meshCell Communication-
dc.subject.meshChemistry, Pharmaceutical-
dc.subject.meshDrug Evaluation-
dc.subject.meshHumans-
dc.subject.meshPhytotherapy-
dc.subject.meshPlants, Medicinal-
dc.subject.meshTropical Medicine-
dc.titleMedicinal plants in tropical medicine. 2. Natural products in cancer treatment from bench to the clinic.en
dc.typeArticleen
dc.contributor.departmentPaterson Institute for Cancer Research, Christie Hospital, Withington, Manchester, UK.en
dc.identifier.journalTransactions of the Royal Society of Tropical Medicine and Hygieneen

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