2.50
Hdl Handle:
http://hdl.handle.net/10541/104743
Title:
Independent clonal origin of T- and B-cell clones in a composite lymphoma.
Authors:
Deane, M; Amlot, P; Pappas, H; Norton, John D
Abstract:
We present a detailed immunohistological and genotypic analysis of an unusual case in which a peripheral T-cell lymphoma, with features of Lennert's and angioimmunoblastic lymphoma, occurred after treatment of a low grade plasmacytoid lymphoma. By analysis of immunoglobulin and T-cell receptor genes, we show that the two diseases had an independent clonal origin at the level of lymphoid commitment. However, by employing a novel polymerase chain reaction-based technique for analysis of B-cell clonality, we show the persistence of a residual minor clonal B-cell population in the subsequent T-cell lymphoma. Only 2 previous cases of composite lymphoma involving B- and T-cell clones have been demonstrated by molecular analysis. This study underlines the immunophenotypic and genotypic heterogeneity of peripheral T-cell lymphomas and illustrates an unusual disease course in which a T-cell lymphoma has arisen in the context of, and perhaps as a consequence of, a B-cell lymphoma.
Affiliation:
Department of Haematology, Royal Free Hospital, London, U.K.
Citation:
Independent clonal origin of T- and B-cell clones in a composite lymphoma. 1991, 15 (9):811-7 Leuk. Res.
Journal:
Leukemia Research
Issue Date:
1991
URI:
http://hdl.handle.net/10541/104743
DOI:
10.1016/0145-2126(91)90465-6
PubMed ID:
1921459
Type:
Article
Language:
en
ISSN:
0145-2126
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorDeane, Men
dc.contributor.authorAmlot, Pen
dc.contributor.authorPappas, Hen
dc.contributor.authorNorton, John Den
dc.date.accessioned2010-06-11T15:23:24Z-
dc.date.available2010-06-11T15:23:24Z-
dc.date.issued1991-
dc.identifier.citationIndependent clonal origin of T- and B-cell clones in a composite lymphoma. 1991, 15 (9):811-7 Leuk. Res.en
dc.identifier.issn0145-2126-
dc.identifier.pmid1921459-
dc.identifier.doi10.1016/0145-2126(91)90465-6-
dc.identifier.urihttp://hdl.handle.net/10541/104743-
dc.description.abstractWe present a detailed immunohistological and genotypic analysis of an unusual case in which a peripheral T-cell lymphoma, with features of Lennert's and angioimmunoblastic lymphoma, occurred after treatment of a low grade plasmacytoid lymphoma. By analysis of immunoglobulin and T-cell receptor genes, we show that the two diseases had an independent clonal origin at the level of lymphoid commitment. However, by employing a novel polymerase chain reaction-based technique for analysis of B-cell clonality, we show the persistence of a residual minor clonal B-cell population in the subsequent T-cell lymphoma. Only 2 previous cases of composite lymphoma involving B- and T-cell clones have been demonstrated by molecular analysis. This study underlines the immunophenotypic and genotypic heterogeneity of peripheral T-cell lymphomas and illustrates an unusual disease course in which a T-cell lymphoma has arisen in the context of, and perhaps as a consequence of, a B-cell lymphoma.en
dc.language.isoenen
dc.subjectSecond Primary Canceren
dc.subjectLeukaemiaen
dc.subject.meshB-Lymphocytes-
dc.subject.meshBiopsy-
dc.subject.meshBlotting, Southern-
dc.subject.meshDNA-
dc.subject.meshDNA Fingerprinting-
dc.subject.meshGene Rearrangement-
dc.subject.meshHumans-
dc.subject.meshImmunoglobulin Heavy Chains-
dc.subject.meshImmunophenotyping-
dc.subject.meshLeukemia, Lymphocytic, Chronic, B-Cell-
dc.subject.meshLymphoma, T-Cell, Peripheral-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasms, Second Primary-
dc.subject.meshPolymerase Chain Reaction-
dc.subject.meshReceptors, Antigen, T-Cell-
dc.subject.meshT-Lymphocytes-
dc.titleIndependent clonal origin of T- and B-cell clones in a composite lymphoma.en
dc.typeArticleen
dc.contributor.departmentDepartment of Haematology, Royal Free Hospital, London, U.K.en
dc.identifier.journalLeukemia Researchen

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