Interactions in recovery and in residual injury from sequential treatments of mouse haemopoietic and stromal marrow cell populations, using X-rays, cyclophosphamide and busulphan.

2.50
Hdl Handle:
http://hdl.handle.net/10541/104741
Title:
Interactions in recovery and in residual injury from sequential treatments of mouse haemopoietic and stromal marrow cell populations, using X-rays, cyclophosphamide and busulphan.
Authors:
Qi, D Y; Hendry, Jolyon H; Testa, Nydia G
Abstract:
The acute recovery of populations of day 11 CFU-S, iv-CFC and CFU-F in mouse bone marrow, following a test dose of X-rays, cyclophosphamide (CP) or busulphan (BUS) given to mice previously treated with repeated priming doses of X-rays or CP, was in general predictable from the amount of residual injury after the priming doses. A marked exception was iv-CFC after X-rays, which although amplified to near normal levels during the residual injury phase, recovered after the test irradiation from low levels of CFU-S. The amount of residual injury after sequential treatments of different agents was in general less than expected on the basis of the product of the effects of the individual agents. This was most marked for CP priming treatments, where the long-term recovery of day 11 CFU-S after the test dose remained persistently above control levels. Also, some correlation was found between improved stromal recovery (CFU-F) and the CFU-S content following the sequential treatment protocols.
Affiliation:
Department of Radiobiology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, U.K.
Citation:
Interactions in recovery and in residual injury from sequential treatments of mouse haemopoietic and stromal marrow cell populations, using X-rays, cyclophosphamide and busulphan. 1991, 20 (1):46-52 Radiother Oncol
Journal:
Radiotherapy and Oncology
Issue Date:
Jan-1991
URI:
http://hdl.handle.net/10541/104741
DOI:
10.1016/0167-8140(91)90111-S
PubMed ID:
2020755
Type:
Article
Language:
en
ISSN:
0167-8140
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorQi, D Yen
dc.contributor.authorHendry, Jolyon Hen
dc.contributor.authorTesta, Nydia Gen
dc.date.accessioned2010-06-11T15:16:48Z-
dc.date.available2010-06-11T15:16:48Z-
dc.date.issued1991-01-
dc.identifier.citationInteractions in recovery and in residual injury from sequential treatments of mouse haemopoietic and stromal marrow cell populations, using X-rays, cyclophosphamide and busulphan. 1991, 20 (1):46-52 Radiother Oncolen
dc.identifier.issn0167-8140-
dc.identifier.pmid2020755-
dc.identifier.doi10.1016/0167-8140(91)90111-S-
dc.identifier.urihttp://hdl.handle.net/10541/104741-
dc.description.abstractThe acute recovery of populations of day 11 CFU-S, iv-CFC and CFU-F in mouse bone marrow, following a test dose of X-rays, cyclophosphamide (CP) or busulphan (BUS) given to mice previously treated with repeated priming doses of X-rays or CP, was in general predictable from the amount of residual injury after the priming doses. A marked exception was iv-CFC after X-rays, which although amplified to near normal levels during the residual injury phase, recovered after the test irradiation from low levels of CFU-S. The amount of residual injury after sequential treatments of different agents was in general less than expected on the basis of the product of the effects of the individual agents. This was most marked for CP priming treatments, where the long-term recovery of day 11 CFU-S after the test dose remained persistently above control levels. Also, some correlation was found between improved stromal recovery (CFU-F) and the CFU-S content following the sequential treatment protocols.en
dc.language.isoenen
dc.subjectHaematopoiesisen
dc.subjectHaematopoietic Stem Cellsen
dc.subject.meshAnimals-
dc.subject.meshBone Marrow-
dc.subject.meshBusulfan-
dc.subject.meshCyclophosphamide-
dc.subject.meshDose-Response Relationship, Drug-
dc.subject.meshDose-Response Relationship, Radiation-
dc.subject.meshHematopoiesis-
dc.subject.meshHematopoietic Stem Cells-
dc.subject.meshMale-
dc.subject.meshMice-
dc.subject.meshMice, Inbred Strains-
dc.subject.meshRadiation Dosage-
dc.subject.meshRadiation Injuries, Experimental-
dc.subject.meshWhole-Body Irradiation-
dc.titleInteractions in recovery and in residual injury from sequential treatments of mouse haemopoietic and stromal marrow cell populations, using X-rays, cyclophosphamide and busulphan.en
dc.typeArticleen
dc.contributor.departmentDepartment of Radiobiology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, U.K.en
dc.identifier.journalRadiotherapy and Oncologyen

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