Cellular immune recognition of HLA-G-expressing choriocarcinoma cell line Jeg-3.

2.50
Hdl Handle:
http://hdl.handle.net/10541/104714
Title:
Cellular immune recognition of HLA-G-expressing choriocarcinoma cell line Jeg-3.
Authors:
Burt, Deborah J; Johnston, Diane; Rinke de Wit, T; Van den Elsen, P; Stern, Peter L
Abstract:
Jeg-3 choriocarcinoma cells express class-I MHC HLA-G and low levels of a novel HLA-C product. The functional significance of such novel MHC class-I expression in regard of the cellular immune response has been investigated. Jeg-3 cells are NK-insensitive, but susceptible to LAK cytotoxicity, some of which is mediated by T cells. No Jeg-3-specific CTL or proliferative responses could be generated in allogeneic responder PBMC from several different donors. There was no detectable xenogeneic recognition of Jeg-3 cells even when preceded by in vivo priming. Jeg-3 cells are able to suppress proliferative responses in humans and others species. This is not reproduced by conditioned medium from the Jeg-3 cells, but can be overridden by IL-2. The ability of the Jeg-3 choriocarcinoma (trophoblast) cells to suppress in the MLR may reflect the processes which are shared to enable the survival of the foetus in a semi-allogeneic mother or a tumour in its host. It is not clear whether there is any relationship between the unusual class-I-MHC expression by trophoblast and the putative regulatory properties of the latter.
Affiliation:
Cancer Research Campaign Department of Immunology, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester, UK.
Citation:
Cellular immune recognition of HLA-G-expressing choriocarcinoma cell line Jeg-3. 1991, 6:117-22 Int. J. Cancer Suppl.
Journal:
International Journal of Cancer. Supplement
Issue Date:
1991
URI:
http://hdl.handle.net/10541/104714
PubMed ID:
2066177
Type:
Article
Language:
en
ISSN:
0898-6924
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorBurt, Deborah Jen
dc.contributor.authorJohnston, Dianeen
dc.contributor.authorRinke de Wit, Ten
dc.contributor.authorVan den Elsen, Pen
dc.contributor.authorStern, Peter Len
dc.date.accessioned2010-06-11T11:36:47Z-
dc.date.available2010-06-11T11:36:47Z-
dc.date.issued1991-
dc.identifier.citationCellular immune recognition of HLA-G-expressing choriocarcinoma cell line Jeg-3. 1991, 6:117-22 Int. J. Cancer Suppl.en
dc.identifier.issn0898-6924-
dc.identifier.pmid2066177-
dc.identifier.urihttp://hdl.handle.net/10541/104714-
dc.description.abstractJeg-3 choriocarcinoma cells express class-I MHC HLA-G and low levels of a novel HLA-C product. The functional significance of such novel MHC class-I expression in regard of the cellular immune response has been investigated. Jeg-3 cells are NK-insensitive, but susceptible to LAK cytotoxicity, some of which is mediated by T cells. No Jeg-3-specific CTL or proliferative responses could be generated in allogeneic responder PBMC from several different donors. There was no detectable xenogeneic recognition of Jeg-3 cells even when preceded by in vivo priming. Jeg-3 cells are able to suppress proliferative responses in humans and others species. This is not reproduced by conditioned medium from the Jeg-3 cells, but can be overridden by IL-2. The ability of the Jeg-3 choriocarcinoma (trophoblast) cells to suppress in the MLR may reflect the processes which are shared to enable the survival of the foetus in a semi-allogeneic mother or a tumour in its host. It is not clear whether there is any relationship between the unusual class-I-MHC expression by trophoblast and the putative regulatory properties of the latter.en
dc.language.isoenen
dc.subjectCancer Transplantationen
dc.subject.meshAnimals-
dc.subject.meshCell Line-
dc.subject.meshChoriocarcinoma-
dc.subject.meshCytotoxicity, Immunologic-
dc.subject.meshDNA Replication-
dc.subject.meshHLA Antigens-
dc.subject.meshHistocompatibility Antigens Class I-
dc.subject.meshHumans-
dc.subject.meshKiller Cells, Lymphokine-Activated-
dc.subject.meshKiller Cells, Natural-
dc.subject.meshLymphocyte Activation-
dc.subject.meshMice-
dc.subject.meshNeoplasm Transplantation-
dc.subject.meshT-Lymphocytes-
dc.subject.meshT-Lymphocytes, Cytotoxic-
dc.subject.meshTeratoma-
dc.subject.meshTransplantation, Heterologous-
dc.titleCellular immune recognition of HLA-G-expressing choriocarcinoma cell line Jeg-3.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Department of Immunology, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester, UK.en
dc.identifier.journalInternational Journal of Cancer. Supplementen

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