2.50
Hdl Handle:
http://hdl.handle.net/10541/104699
Title:
Growth inhibitory effects of transforming growth factor-beta 1 in vivo.
Authors:
Migdalska, Agnieszka; Molineux, Graham; Demuynck, Hilde; Evans, Gareth S; Ruscetti, F; Dexter, T Michael
Abstract:
Transforming growth factor-beta (TGF-beta) can reversibly inhibit the in vitro proliferation of murine and human haemopoietic progenitors and some of their more developmentally restricted progeny. Using an assay for measuring day 8 and day 11 CFU-S, TGF-beta caused a gradual decline in the number of CFU-S undergoing DNA synthesis so that after 5 days of daily treatment only quiescent cells were found. Release of this growth inhibition was seen within 24 hours post-treatment with recovery of all progenitors to normal levels. Similar inhibitory effects of TGF-beta were seen on the cells of the intestinal epithelium, indicating that TGF-beta is a general stem cell growth inhibitor. These results suggest that TGF-beta can be used as a cytostatic agent to protect normal stem cells in patients being treated with cell cycle-specific cytotoxic agents.
Affiliation:
Department of Experimental Haematology, Paterson Institute for Cancer Research, Manchester, England.
Citation:
Growth inhibitory effects of transforming growth factor-beta 1 in vivo. 1991, 4 (3):239-45 Growth Factors
Journal:
Growth Factors
Issue Date:
1991
URI:
http://hdl.handle.net/10541/104699
DOI:
10.3109/08977199109104820
PubMed ID:
1768436
Type:
Article
Language:
en
ISSN:
0897-7194
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorMigdalska, Agnieszkaen
dc.contributor.authorMolineux, Grahamen
dc.contributor.authorDemuynck, Hildeen
dc.contributor.authorEvans, Gareth Sen
dc.contributor.authorRuscetti, Fen
dc.contributor.authorDexter, T Michaelen
dc.date.accessioned2010-06-11T11:27:25Z-
dc.date.available2010-06-11T11:27:25Z-
dc.date.issued1991-
dc.identifier.citationGrowth inhibitory effects of transforming growth factor-beta 1 in vivo. 1991, 4 (3):239-45 Growth Factorsen
dc.identifier.issn0897-7194-
dc.identifier.pmid1768436-
dc.identifier.doi10.3109/08977199109104820-
dc.identifier.urihttp://hdl.handle.net/10541/104699-
dc.description.abstractTransforming growth factor-beta (TGF-beta) can reversibly inhibit the in vitro proliferation of murine and human haemopoietic progenitors and some of their more developmentally restricted progeny. Using an assay for measuring day 8 and day 11 CFU-S, TGF-beta caused a gradual decline in the number of CFU-S undergoing DNA synthesis so that after 5 days of daily treatment only quiescent cells were found. Release of this growth inhibition was seen within 24 hours post-treatment with recovery of all progenitors to normal levels. Similar inhibitory effects of TGF-beta were seen on the cells of the intestinal epithelium, indicating that TGF-beta is a general stem cell growth inhibitor. These results suggest that TGF-beta can be used as a cytostatic agent to protect normal stem cells in patients being treated with cell cycle-specific cytotoxic agents.en
dc.language.isoenen
dc.subjectHaematopoietic Stem Cells-
dc.subject.meshAnimals-
dc.subject.meshBone Marrow-
dc.subject.meshCell Division-
dc.subject.meshColony-Forming Units Assay-
dc.subject.meshFemale-
dc.subject.meshGrowth Inhibitors-
dc.subject.meshHematopoietic Stem Cells-
dc.subject.meshIntestine, Small-
dc.subject.meshMice-
dc.subject.meshSpleen-
dc.subject.meshTransforming Growth Factor beta-
dc.titleGrowth inhibitory effects of transforming growth factor-beta 1 in vivo.en
dc.typeArticleen
dc.contributor.departmentDepartment of Experimental Haematology, Paterson Institute for Cancer Research, Manchester, England.en
dc.identifier.journalGrowth Factorsen

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