Changes in the hormone dependency of epithelial cell proliferation in the genital tract of mice following neonatal oestrogen treatment.

2.50
Hdl Handle:
http://hdl.handle.net/10541/104686
Title:
Changes in the hormone dependency of epithelial cell proliferation in the genital tract of mice following neonatal oestrogen treatment.
Authors:
Gibson, D F; Roberts, Stephen A; Evans, Gareth S
Abstract:
The genital tract epithelium of the female laboratory mouse has been widely studied as a model of oestrogen-dependent growth and proliferation. Perturbation of the hormonal imprinting of these tissues during neonatal development has also been used to study the development of pathological abnormalities, particularly in the cervical epithelium. This study demonstrates that mice treated neonatally from days 1-5 with supraphysiological concentrations of oestrogen are able to maintain high levels of proliferation following the removal of the ovaries later in adult life. This high level of proliferation was shown to be independent of the ovarian oestrogens and of oestrogens produced peripherally by aromatisation. These results suggest conversion of the genital tract in these mice to a fully hormonal "independent" state. However, neonatal treatment with oestrogen was not found to produce a uniform change to hormonal independence. Further challenge of the adult ovariectomised mice with oestrogen, demonstrated that a population of cells still retained the ability to respond to the mitogenic influence of this hormone.
Affiliation:
Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, U.K.
Citation:
Changes in the hormone dependency of epithelial cell proliferation in the genital tract of mice following neonatal oestrogen treatment. 1991, 27 (10):1295-301 Eur. J. Cancer
Journal:
European Journal of Cancer
Issue Date:
1991
URI:
http://hdl.handle.net/10541/104686
PubMed ID:
1835602
Type:
Article
Language:
en
ISSN:
0959-8049
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorGibson, D Fen
dc.contributor.authorRoberts, Stephen Aen
dc.contributor.authorEvans, Gareth Sen
dc.date.accessioned2010-06-11T10:56:54Z-
dc.date.available2010-06-11T10:56:54Z-
dc.date.issued1991-
dc.identifier.citationChanges in the hormone dependency of epithelial cell proliferation in the genital tract of mice following neonatal oestrogen treatment. 1991, 27 (10):1295-301 Eur. J. Canceren
dc.identifier.issn0959-8049-
dc.identifier.pmid1835602-
dc.identifier.urihttp://hdl.handle.net/10541/104686-
dc.description.abstractThe genital tract epithelium of the female laboratory mouse has been widely studied as a model of oestrogen-dependent growth and proliferation. Perturbation of the hormonal imprinting of these tissues during neonatal development has also been used to study the development of pathological abnormalities, particularly in the cervical epithelium. This study demonstrates that mice treated neonatally from days 1-5 with supraphysiological concentrations of oestrogen are able to maintain high levels of proliferation following the removal of the ovaries later in adult life. This high level of proliferation was shown to be independent of the ovarian oestrogens and of oestrogens produced peripherally by aromatisation. These results suggest conversion of the genital tract in these mice to a fully hormonal "independent" state. However, neonatal treatment with oestrogen was not found to produce a uniform change to hormonal independence. Further challenge of the adult ovariectomised mice with oestrogen, demonstrated that a population of cells still retained the ability to respond to the mitogenic influence of this hormone.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshAnimals, Newborn-
dc.subject.meshAromatase-
dc.subject.meshCell Count-
dc.subject.meshCell Division-
dc.subject.meshEpithelium-
dc.subject.meshEstradiol-
dc.subject.meshFemale-
dc.subject.meshGenitalia, Female-
dc.subject.meshMice-
dc.subject.meshMice, Inbred Strains-
dc.subject.meshOvariectomy-
dc.subject.meshThymidine-
dc.titleChanges in the hormone dependency of epithelial cell proliferation in the genital tract of mice following neonatal oestrogen treatment.en
dc.typeArticleen
dc.contributor.departmentDepartment of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, U.K.en
dc.identifier.journalEuropean Journal of Canceren
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