Promutagenic lesions persist in the DNA of target cells for nitrosamine-induced carcinogenesis.

2.50
Hdl Handle:
http://hdl.handle.net/10541/104685
Title:
Promutagenic lesions persist in the DNA of target cells for nitrosamine-induced carcinogenesis.
Authors:
Fan, Chun-Yang; Butler, W H; O'Connor, Peter J
Abstract:
Immunohistochemical procedures for the location of O6-methylguanine (O6-meGua) permit detection of cells proficient for the metabolism of N-nitrosodimethylamine (NDMA) and deficient for the repair of this DNA lesion. Such cells are potentially at high risk for cancer induction and are present in various tissues. In animals maintained on a protein-deficient diet, the distribution and intensity of alkylation of individual cells is altered, particularly in liver where fewer cells apparently retain the capacity to metabolize the nitrosamine, thereby permitting increased levels of alkylation in other tissues. In the renal cortex, specific, O6-meGua-positive target cells for renal cancer induced by a single dose of NDMA in weanling rats persist at least up to the appearance of early lesions. Persistence of alkylated cells in several tissues indicates prospects for the detection of environmental exposure.
Affiliation:
CRC Department of Carcinogenesis, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester, UK.
Citation:
Promutagenic lesions persist in the DNA of target cells for nitrosamine-induced carcinogenesis. 1991 (105):119-22 IARC Sci. Publ.
Journal:
IARC Scientific Publications
Issue Date:
1991
URI:
http://hdl.handle.net/10541/104685
PubMed ID:
1855834
Type:
Article
Language:
en
ISSN:
0300-5038
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorFan, Chun-Yangen
dc.contributor.authorButler, W Hen
dc.contributor.authorO'Connor, Peter Jen
dc.date.accessioned2010-06-11T10:55:23Z-
dc.date.available2010-06-11T10:55:23Z-
dc.date.issued1991-
dc.identifier.citationPromutagenic lesions persist in the DNA of target cells for nitrosamine-induced carcinogenesis. 1991 (105):119-22 IARC Sci. Publ.en
dc.identifier.issn0300-5038-
dc.identifier.pmid1855834-
dc.identifier.urihttp://hdl.handle.net/10541/104685-
dc.description.abstractImmunohistochemical procedures for the location of O6-methylguanine (O6-meGua) permit detection of cells proficient for the metabolism of N-nitrosodimethylamine (NDMA) and deficient for the repair of this DNA lesion. Such cells are potentially at high risk for cancer induction and are present in various tissues. In animals maintained on a protein-deficient diet, the distribution and intensity of alkylation of individual cells is altered, particularly in liver where fewer cells apparently retain the capacity to metabolize the nitrosamine, thereby permitting increased levels of alkylation in other tissues. In the renal cortex, specific, O6-meGua-positive target cells for renal cancer induced by a single dose of NDMA in weanling rats persist at least up to the appearance of early lesions. Persistence of alkylated cells in several tissues indicates prospects for the detection of environmental exposure.en
dc.language.isoenen
dc.subjectExperimental Canceren
dc.subject.meshAlkylation-
dc.subject.meshAnimals-
dc.subject.meshDNA Damage-
dc.subject.meshDimethylnitrosamine-
dc.subject.meshGuanine-
dc.subject.meshMale-
dc.subject.meshNeoplasms, Experimental-
dc.subject.meshRats-
dc.titlePromutagenic lesions persist in the DNA of target cells for nitrosamine-induced carcinogenesis.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Carcinogenesis, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester, UK.en
dc.identifier.journalIARC Scientific Publicationsen
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