Dimethanesulphonate esters in receptor mapping studies. 1. Benzene 1,2-, 1,3- and 1,4-diol, dimethanol and diethanol dimethanesulphonates and anti-tumour activity.

2.50
Hdl Handle:
http://hdl.handle.net/10541/104669
Title:
Dimethanesulphonate esters in receptor mapping studies. 1. Benzene 1,2-, 1,3- and 1,4-diol, dimethanol and diethanol dimethanesulphonates and anti-tumour activity.
Authors:
Fox, Brian W; Hadfield, John A; O'Connor, P M
Abstract:
The anti-tumour activities of nine aromatic dimethanesulphonate esters were examined. Their biological effects have been related to both their chemical reactivity and to the computer-modelled vectorial positions of the centres of alkylation of the compounds. One compound (19) has shown activity between sensitive and resistant Yoshida tumours in vivo and also shows the highest activity between these two cell lines in vitro. In its minimal energy form, this compound would require to interact with converging nucleophilic centres about 6 A apart, and it is tentatively suggested that this may be an appropriate dimension for a receptor which is required to be alkylated in order to show anti-tumour activity.
Affiliation:
Department of Experimental Chemotherapy, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Withington, Manchester, UK.
Citation:
Dimethanesulphonate esters in receptor mapping studies. 1. Benzene 1,2-, 1,3- and 1,4-diol, dimethanol and diethanol dimethanesulphonates and anti-tumour activity. 1991, 6 (2):71-82 Anticancer Drug Des.
Journal:
Anticancer Drug Design
Issue Date:
May-1991
URI:
http://hdl.handle.net/10541/104669
PubMed ID:
2039583
Type:
Article
Language:
en
ISSN:
0266-9536
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorFox, Brian Wen
dc.contributor.authorHadfield, John Aen
dc.contributor.authorO'Connor, P Men
dc.date.accessioned2010-06-11T10:16:34Z-
dc.date.available2010-06-11T10:16:34Z-
dc.date.issued1991-05-
dc.identifier.citationDimethanesulphonate esters in receptor mapping studies. 1. Benzene 1,2-, 1,3- and 1,4-diol, dimethanol and diethanol dimethanesulphonates and anti-tumour activity. 1991, 6 (2):71-82 Anticancer Drug Des.en
dc.identifier.issn0266-9536-
dc.identifier.pmid2039583-
dc.identifier.urihttp://hdl.handle.net/10541/104669-
dc.description.abstractThe anti-tumour activities of nine aromatic dimethanesulphonate esters were examined. Their biological effects have been related to both their chemical reactivity and to the computer-modelled vectorial positions of the centres of alkylation of the compounds. One compound (19) has shown activity between sensitive and resistant Yoshida tumours in vivo and also shows the highest activity between these two cell lines in vitro. In its minimal energy form, this compound would require to interact with converging nucleophilic centres about 6 A apart, and it is tentatively suggested that this may be an appropriate dimension for a receptor which is required to be alkylated in order to show anti-tumour activity.en
dc.language.isoenen
dc.subjectCultured Tumour Cellsen
dc.subject.meshAnimals-
dc.subject.meshAntineoplastic Agents-
dc.subject.meshBinding Sites-
dc.subject.meshBody Weight-
dc.subject.meshComputer Simulation-
dc.subject.meshHalf-Life-
dc.subject.meshIsomerism-
dc.subject.meshLethal Dose 50-
dc.subject.meshMale-
dc.subject.meshMethyl Methanesulfonate-
dc.subject.meshModels, Molecular-
dc.subject.meshRats-
dc.subject.meshReceptors, Drug-
dc.subject.meshSolubility-
dc.subject.meshStructure-Activity Relationship-
dc.subject.meshTumor Cells, Cultured-
dc.titleDimethanesulphonate esters in receptor mapping studies. 1. Benzene 1,2-, 1,3- and 1,4-diol, dimethanol and diethanol dimethanesulphonates and anti-tumour activity.en
dc.typeArticleen
dc.contributor.departmentDepartment of Experimental Chemotherapy, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Withington, Manchester, UK.en
dc.identifier.journalAnticancer Drug Designen
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