The sensitivity of human tissues to changes in dose fractionation: deductions from the RCR survey among UK radiotherapists.

2.50
Hdl Handle:
http://hdl.handle.net/10541/104597
Title:
The sensitivity of human tissues to changes in dose fractionation: deductions from the RCR survey among UK radiotherapists.
Authors:
Hendry, Jolyon H; Roberts, Stephen A
Abstract:
The dosage prescriptions reported in the Royal College of Radiologists' fractionation survey among radiotherapists have been further analysed using model equations in order to deduce estimates of fractionation-sensitivity parameters for each of the six cases under consideration. For example, using the linear-quadratic model, including a (significant) time factor, with radical treatments of a T2 breast carcinoma or a T1N0 squamous carcinoma of the vocal cord, the (alpha/beta) ratios were 26 +/- 20 Gy and 37 +/- 46 Gy, respectively. The values of the time factor, expressed as the maximum extra dose required per day to counteract the decrease in effect with increasing overall time (gamma/alpha), were 0.60 and 0.45 Gy/day respectively. Using the Ellis formula, which provided a significantly better fit to the dosage prescription (P = 0.003), the exponents of N were calculated to be 0.24 +/- 0.05 and 0.27 +/- 0.07, respectively. The corresponding values of the T exponent were 0.16 +/- 0.06 and 0.014 +/- 0.075. About 20% of radiotherapists prescribed doses greater than +/- 10% from the mean fitted values for the breast treatment, and about 6% of them in the case of the vocal cord.
Affiliation:
Cancer Research Campaign Department, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester, UK.
Citation:
The sensitivity of human tissues to changes in dose fractionation: deductions from the RCR survey among UK radiotherapists. 1991, 3 (1):22-7 Clin Oncol (R Coll Radiol)
Journal:
Clinical Oncology
Issue Date:
Jan-1991
URI:
http://hdl.handle.net/10541/104597
DOI:
10.1016/S0936-6555(05)81151-3
PubMed ID:
2001338
Type:
Article
Language:
en
ISSN:
0936-6555
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorHendry, Jolyon Hen
dc.contributor.authorRoberts, Stephen Aen
dc.date.accessioned2010-06-10T08:48:26Z-
dc.date.available2010-06-10T08:48:26Z-
dc.date.issued1991-01-
dc.identifier.citationThe sensitivity of human tissues to changes in dose fractionation: deductions from the RCR survey among UK radiotherapists. 1991, 3 (1):22-7 Clin Oncol (R Coll Radiol)en
dc.identifier.issn0936-6555-
dc.identifier.pmid2001338-
dc.identifier.doi10.1016/S0936-6555(05)81151-3-
dc.identifier.urihttp://hdl.handle.net/10541/104597-
dc.description.abstractThe dosage prescriptions reported in the Royal College of Radiologists' fractionation survey among radiotherapists have been further analysed using model equations in order to deduce estimates of fractionation-sensitivity parameters for each of the six cases under consideration. For example, using the linear-quadratic model, including a (significant) time factor, with radical treatments of a T2 breast carcinoma or a T1N0 squamous carcinoma of the vocal cord, the (alpha/beta) ratios were 26 +/- 20 Gy and 37 +/- 46 Gy, respectively. The values of the time factor, expressed as the maximum extra dose required per day to counteract the decrease in effect with increasing overall time (gamma/alpha), were 0.60 and 0.45 Gy/day respectively. Using the Ellis formula, which provided a significantly better fit to the dosage prescription (P = 0.003), the exponents of N were calculated to be 0.24 +/- 0.05 and 0.27 +/- 0.07, respectively. The corresponding values of the T exponent were 0.16 +/- 0.06 and 0.014 +/- 0.075. About 20% of radiotherapists prescribed doses greater than +/- 10% from the mean fitted values for the breast treatment, and about 6% of them in the case of the vocal cord.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectBronchial Canceren
dc.subjectCanceren
dc.subjectRectal Canceren
dc.subject.meshAged-
dc.subject.meshBreast Neoplasms-
dc.subject.meshBronchial Neoplasms-
dc.subject.meshCarcinoma, Squamous Cell-
dc.subject.meshData Interpretation, Statistical-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasms-
dc.subject.meshRadiation Tolerance-
dc.subject.meshRadiotherapy Dosage-
dc.subject.meshRectal Neoplasms-
dc.titleThe sensitivity of human tissues to changes in dose fractionation: deductions from the RCR survey among UK radiotherapists.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Department, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester, UK.en
dc.identifier.journalClinical Oncologyen
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