Migration stimulating activity in serum of breast cancer patients.

2.50
Hdl Handle:
http://hdl.handle.net/10541/104594
Title:
Migration stimulating activity in serum of breast cancer patients.
Authors:
Picardo, M; Schor, Seth L; Grey, A M; Howell, Anthony ( 0000-0002-6233-719X ) ; Laidlaw, Ian; Redford, Judy; Schor, Ana M
Abstract:
An assay to measure the ability to stimulate migration of fibroblasts into collagen gel was carried out on serum from treated and untreated breast cancer patients and from healthy controls. Migration stimulating activity was found in the serum of 10 (83%) of 12 untreated breast cancer patients immediately before surgical resection of the primary tumour and in 9 (75%) of them 4 days after resection; in 13 (93%) of 14 patients 1-13 years after tumour resection who had received adjuvant treatment; and in 2 (10%) of 20 healthy women matched for age. The migration stimulating activity in cancer patients' serum was indistinguishable from the migration stimulating factor produced in vitro by fetal and cancer patient skin fibroblasts in its behaviour in various biochemical fractionation procedures. The presence of this activity in the serum of treated breast cancer patients clearly distinguishes it from other oncofetal proteins, which all seem to be produced by tumours.
Affiliation:
Department of Cell and Structural Biology, University of Manchester, UK.
Citation:
Migration stimulating activity in serum of breast cancer patients. 1991, 337 (8734):130-3 Lancet
Journal:
Lancet
Issue Date:
19-Jan-1991
URI:
http://hdl.handle.net/10541/104594
DOI:
10.1016/0140-6736(91)90798-T
PubMed ID:
1670786
Type:
Article
Language:
en
ISSN:
0140-6736
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorPicardo, Men
dc.contributor.authorSchor, Seth Len
dc.contributor.authorGrey, A Men
dc.contributor.authorHowell, Anthonyen
dc.contributor.authorLaidlaw, Ianen
dc.contributor.authorRedford, Judyen
dc.contributor.authorSchor, Ana Men
dc.date.accessioned2010-06-10T08:29:47Z-
dc.date.available2010-06-10T08:29:47Z-
dc.date.issued1991-01-19-
dc.identifier.citationMigration stimulating activity in serum of breast cancer patients. 1991, 337 (8734):130-3 Lanceten
dc.identifier.issn0140-6736-
dc.identifier.pmid1670786-
dc.identifier.doi10.1016/0140-6736(91)90798-T-
dc.identifier.urihttp://hdl.handle.net/10541/104594-
dc.description.abstractAn assay to measure the ability to stimulate migration of fibroblasts into collagen gel was carried out on serum from treated and untreated breast cancer patients and from healthy controls. Migration stimulating activity was found in the serum of 10 (83%) of 12 untreated breast cancer patients immediately before surgical resection of the primary tumour and in 9 (75%) of them 4 days after resection; in 13 (93%) of 14 patients 1-13 years after tumour resection who had received adjuvant treatment; and in 2 (10%) of 20 healthy women matched for age. The migration stimulating activity in cancer patients' serum was indistinguishable from the migration stimulating factor produced in vitro by fetal and cancer patient skin fibroblasts in its behaviour in various biochemical fractionation procedures. The presence of this activity in the serum of treated breast cancer patients clearly distinguishes it from other oncofetal proteins, which all seem to be produced by tumours.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshBreast Neoplasms-
dc.subject.meshCell Movement-
dc.subject.meshCytokines-
dc.subject.meshFemale-
dc.subject.meshFibroblasts-
dc.subject.meshHumans-
dc.subject.meshMiddle Aged-
dc.subject.meshPredictive Value of Tests-
dc.titleMigration stimulating activity in serum of breast cancer patients.en
dc.typeArticleen
dc.contributor.departmentDepartment of Cell and Structural Biology, University of Manchester, UK.en
dc.identifier.journalLanceten

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