Twelve cases of Ki-1 positive anaplastic large cell lymphoma of skin.

2.50
Hdl Handle:
http://hdl.handle.net/10541/104536
Title:
Twelve cases of Ki-1 positive anaplastic large cell lymphoma of skin.
Authors:
Banerjee, Saumitra S; Heald, J; Harris, Martin
Abstract:
In seven of 12 cases of Ber-H2 (Ki-1) positive anaplastic large cell non-Hodgkin's lymphoma (Ki-1 ALCL) disease remained localised to skin, and in five there was extracutaneous spread. Four patients had histological evidence of pre-existing or coexisting mycosis fungoides, and three patients had a long standing history of eczema or ichthyosis. In two cases the presence of a T phenotype was shown in frozen sections, and in a further six cases a T phenotype was firmly established in paraffin wax sections. Four patients died less than one year after presentation (two with disseminated lymphoma; two from other causes); one died at five years with widespread lymphoma and the remaining seven cases were alive one to 14 1/2 years after presentation. Three of the four patients with associated mycosis fungoides had prolonged survival, contrary to the findings of previous reports which suggest secondary Ki-1 ALCL behaves aggressively. The recognition of these tumours is important because of their relatively good prognosis. The diagnosis can be readily substantiated immunohistochemically, using a simple panel of antibodies.
Affiliation:
Department of Histopathology, Christie Hospital and Holt Radium Institute, Manchester.
Citation:
Twelve cases of Ki-1 positive anaplastic large cell lymphoma of skin. 1991, 44 (2):119-25 J. Clin. Pathol.
Journal:
Journal of Clinical Pathology
Issue Date:
Feb-1991
URI:
http://hdl.handle.net/10541/104536
DOI:
10.1136/jcp.44.2.119
PubMed ID:
1650796
Type:
Article
Language:
en
ISSN:
0021-9746
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorBanerjee, Saumitra Sen
dc.contributor.authorHeald, Jen
dc.contributor.authorHarris, Martinen
dc.date.accessioned2010-06-09T16:30:19Z-
dc.date.available2010-06-09T16:30:19Z-
dc.date.issued1991-02-
dc.identifier.citationTwelve cases of Ki-1 positive anaplastic large cell lymphoma of skin. 1991, 44 (2):119-25 J. Clin. Pathol.en
dc.identifier.issn0021-9746-
dc.identifier.pmid1650796-
dc.identifier.doi10.1136/jcp.44.2.119-
dc.identifier.urihttp://hdl.handle.net/10541/104536-
dc.description.abstractIn seven of 12 cases of Ber-H2 (Ki-1) positive anaplastic large cell non-Hodgkin's lymphoma (Ki-1 ALCL) disease remained localised to skin, and in five there was extracutaneous spread. Four patients had histological evidence of pre-existing or coexisting mycosis fungoides, and three patients had a long standing history of eczema or ichthyosis. In two cases the presence of a T phenotype was shown in frozen sections, and in a further six cases a T phenotype was firmly established in paraffin wax sections. Four patients died less than one year after presentation (two with disseminated lymphoma; two from other causes); one died at five years with widespread lymphoma and the remaining seven cases were alive one to 14 1/2 years after presentation. Three of the four patients with associated mycosis fungoides had prolonged survival, contrary to the findings of previous reports which suggest secondary Ki-1 ALCL behaves aggressively. The recognition of these tumours is important because of their relatively good prognosis. The diagnosis can be readily substantiated immunohistochemically, using a simple panel of antibodies.en
dc.language.isoenen
dc.subjectCancer Antigensen
dc.subjectSkin Canceren
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAntibodies, Monoclonal-
dc.subject.meshAntigens, CD-
dc.subject.meshAntigens, CD30-
dc.subject.meshAntigens, Neoplasm-
dc.subject.meshBiological Markers-
dc.subject.meshEczema-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshIchthyosis-
dc.subject.meshImmunohistochemistry-
dc.subject.meshLymph Nodes-
dc.subject.meshLymphoma, Large B-Cell, Diffuse-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshMycosis Fungoides-
dc.subject.meshSkin Neoplasms-
dc.titleTwelve cases of Ki-1 positive anaplastic large cell lymphoma of skin.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital and Holt Radium Institute, Manchester.en
dc.identifier.journalJournal of Clinical Pathologyen

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