Late BCNU lung: a light and ultrastructural study on the delayed effect of BCNU on the lung parenchyma.

2.50
Hdl Handle:
http://hdl.handle.net/10541/104535
Title:
Late BCNU lung: a light and ultrastructural study on the delayed effect of BCNU on the lung parenchyma.
Authors:
Hasleton, Philip S; O'Driscoll, B R; Lynch, P; Webster, A; Kalra, S J; Gattamaneni, Rao; Woodcock, A A; Poulter, L W
Abstract:
We describe eight patients who developed interstitial pulmonary fibrosis following BCNU (carmustine) therapy for cerebral tumours. The fibrosis presented 12-17 (mean 14) years after exposure to the drug. A distinctive pattern of pulmonary fibrosis with involvement of the apices and subpleural areas was seen in one patient dying of the disease. Light microscopy showed interstitial elastosis and intra-alveolar fibrosis which was often focal with an associated mild lymphoplasmacytic infiltrate, intra-alveolar oedema, macrophages, and some neutrophils. Ultrastructural studies showed electron lucency of type I pneumocytes, with breaks in the cytoplasmic membranes leaving a bare basement membrane. Degenerative change was also seen in endothelial cell cytoplasm along with lipofuscin deposition. While BCNU pulmonary fibrosis has been described up to 2 years after treatment, this complication so late after therapy, though rare, has important implications for the follow-up of patients receiving this drug.
Affiliation:
Department of Pathology, Wythenshawe Hospital, Manchester, U.K.
Citation:
Late BCNU lung: a light and ultrastructural study on the delayed effect of BCNU on the lung parenchyma. 1991, 164 (1):31-6 J. Pathol.
Journal:
The Journal of Pathology
Issue Date:
May-1991
URI:
http://hdl.handle.net/10541/104535
DOI:
10.1002/path.1711640106
PubMed ID:
2056387
Type:
Article
Language:
en
ISSN:
0022-3417
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorHasleton, Philip Sen
dc.contributor.authorO'Driscoll, B Ren
dc.contributor.authorLynch, Pen
dc.contributor.authorWebster, Aen
dc.contributor.authorKalra, S Jen
dc.contributor.authorGattamaneni, Raoen
dc.contributor.authorWoodcock, A Aen
dc.contributor.authorPoulter, L Wen
dc.date.accessioned2010-06-09T16:23:02Z-
dc.date.available2010-06-09T16:23:02Z-
dc.date.issued1991-05-
dc.identifier.citationLate BCNU lung: a light and ultrastructural study on the delayed effect of BCNU on the lung parenchyma. 1991, 164 (1):31-6 J. Pathol.en
dc.identifier.issn0022-3417-
dc.identifier.pmid2056387-
dc.identifier.doi10.1002/path.1711640106-
dc.identifier.urihttp://hdl.handle.net/10541/104535-
dc.description.abstractWe describe eight patients who developed interstitial pulmonary fibrosis following BCNU (carmustine) therapy for cerebral tumours. The fibrosis presented 12-17 (mean 14) years after exposure to the drug. A distinctive pattern of pulmonary fibrosis with involvement of the apices and subpleural areas was seen in one patient dying of the disease. Light microscopy showed interstitial elastosis and intra-alveolar fibrosis which was often focal with an associated mild lymphoplasmacytic infiltrate, intra-alveolar oedema, macrophages, and some neutrophils. Ultrastructural studies showed electron lucency of type I pneumocytes, with breaks in the cytoplasmic membranes leaving a bare basement membrane. Degenerative change was also seen in endothelial cell cytoplasm along with lipofuscin deposition. While BCNU pulmonary fibrosis has been described up to 2 years after treatment, this complication so late after therapy, though rare, has important implications for the follow-up of patients receiving this drug.en
dc.language.isoenen
dc.subjectBrain Canceren
dc.subject.meshAstrocytoma-
dc.subject.meshBiopsy-
dc.subject.meshBrain Neoplasms-
dc.subject.meshCarmustine-
dc.subject.meshEpendymoma-
dc.subject.meshHumans-
dc.subject.meshLung-
dc.subject.meshMedulloblastoma-
dc.subject.meshMicroscopy, Electron-
dc.subject.meshPulmonary Fibrosis-
dc.subject.meshTime Factors-
dc.titleLate BCNU lung: a light and ultrastructural study on the delayed effect of BCNU on the lung parenchyma.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, Wythenshawe Hospital, Manchester, U.K.en
dc.identifier.journalThe Journal of Pathologyen

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