Synergistic interactions in haemopoiesis: biological implications and clinical use.

2.50
Hdl Handle:
http://hdl.handle.net/10541/101865
Title:
Synergistic interactions in haemopoiesis: biological implications and clinical use.
Authors:
Dexter, T Michael
Abstract:
Growth factors promote the survival and proliferation of haemopoietic stem and progenitor cells, and in their absence the haemopoietic cells undergo apoptosis and die. The results of studies reported here indicate that multipotent stem cells have receptors for most, if not all, of the growth factors, but that even saturated binding of the receptors for a single growth factor is not sufficient to transduce an effective stimulus for the proliferation of these cells (possibly due to very low receptor numbers). However, when the growth factors are combined synergistic effects can be seen. Studies in which stem cell factor was used in combination with other growth factors showed that stem cell factor allowed the survival of stem cells, while a second growth factor (granulocyte-macrophage colony-stimulating factor) stimulated the stem cells to develop normally. Stem cell factor was also shown to alter the dose-response relationships of developing haemopoietic cells for other growth factors.
Affiliation:
Christie Hospital, Withington, Manchester, UK.
Citation:
Synergistic interactions in haemopoiesis: biological implications and clinical use. 1993, 29A Suppl 3:S6-9 Eur. J. Cancer
Journal:
European Journal of Cancer
Issue Date:
1993
URI:
http://hdl.handle.net/10541/101865
DOI:
10.1016/0959-8049(93)90624-O
PubMed ID:
8398366
Type:
Article
Language:
en
ISSN:
0959-8049
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorDexter, T Michaelen
dc.date.accessioned2010-06-07T17:21:31Z-
dc.date.available2010-06-07T17:21:31Z-
dc.date.issued1993-
dc.identifier.citationSynergistic interactions in haemopoiesis: biological implications and clinical use. 1993, 29A Suppl 3:S6-9 Eur. J. Canceren
dc.identifier.issn0959-8049-
dc.identifier.pmid8398366-
dc.identifier.doi10.1016/0959-8049(93)90624-O-
dc.identifier.urihttp://hdl.handle.net/10541/101865-
dc.description.abstractGrowth factors promote the survival and proliferation of haemopoietic stem and progenitor cells, and in their absence the haemopoietic cells undergo apoptosis and die. The results of studies reported here indicate that multipotent stem cells have receptors for most, if not all, of the growth factors, but that even saturated binding of the receptors for a single growth factor is not sufficient to transduce an effective stimulus for the proliferation of these cells (possibly due to very low receptor numbers). However, when the growth factors are combined synergistic effects can be seen. Studies in which stem cell factor was used in combination with other growth factors showed that stem cell factor allowed the survival of stem cells, while a second growth factor (granulocyte-macrophage colony-stimulating factor) stimulated the stem cells to develop normally. Stem cell factor was also shown to alter the dose-response relationships of developing haemopoietic cells for other growth factors.en
dc.language.isoenen
dc.subjectHaematopoiesisen
dc.subjectHaematopoietic Stem Cellsen
dc.subjectHaematopoietic Cell Growth Factorsen
dc.subject.meshBone Marrow Cells-
dc.subject.meshCell Division-
dc.subject.meshHematopoiesis-
dc.subject.meshHematopoietic Cell Growth Factors-
dc.subject.meshHematopoietic Stem Cells-
dc.subject.meshHumans-
dc.titleSynergistic interactions in haemopoiesis: biological implications and clinical use.en
dc.typeArticleen
dc.contributor.departmentChristie Hospital, Withington, Manchester, UK.en
dc.identifier.journalEuropean Journal of Canceren

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