2.50
Hdl Handle:
http://hdl.handle.net/10541/101830
Title:
The uptake of porphyrin and zinc-metalloporphyrin by the primate prostate.
Authors:
Pantelides, M L; Moore, James V; Forbes, E; Truscott, T G; Blacklock, N J
Abstract:
The relative distribution of sensitizer drugs in the prostate and its contiguous organs is of importance in the treatment of localized prostatic cancer with photodynamic therapy. Using the primate model, whose prostate is both morphologically and physiologically homologous with its human counterpart, the distribution of hematoporphyrin derivative (HpD) amongst organs of urological interest was determined. Hematoporphyrin derivative levels were comparatively low in both caudal and cranial prostatic lobes (0.93-1.77 micrograms/g) and were similar to those in rectum, urethra and the skin. The reticuloendothelial organs, liver, spleen and also the kidney accumulated the highest quantities of porphyrin (4.76-9.8 micrograms/g, liver > spleen > kidney). Despite a high avidity of prostatic tissue for zinc, a zinc-metalloporphyrin (Zn-HpD) did not concentrate selectively in the prostate. The results are of clinical value in view of the homology between the primate and the human.
Affiliation:
University Department of Urology, University Hospital of South Manchester, West Didsbury, U.K.
Citation:
The uptake of porphyrin and zinc-metalloporphyrin by the primate prostate. 1993, 57 (5):838-41 Photochem. Photobiol.
Journal:
Photochemistry and Photobiology
Issue Date:
May-1993
URI:
http://hdl.handle.net/10541/101830
PubMed ID:
8337257
Type:
Article
Language:
en
ISSN:
0031-8655
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorPantelides, M Len
dc.contributor.authorMoore, James Ven
dc.contributor.authorForbes, Een
dc.contributor.authorTruscott, T Gen
dc.contributor.authorBlacklock, N Jen
dc.date.accessioned2010-06-07T16:05:17Z-
dc.date.available2010-06-07T16:05:17Z-
dc.date.issued1993-05-
dc.identifier.citationThe uptake of porphyrin and zinc-metalloporphyrin by the primate prostate. 1993, 57 (5):838-41 Photochem. Photobiol.en
dc.identifier.issn0031-8655-
dc.identifier.pmid8337257-
dc.identifier.urihttp://hdl.handle.net/10541/101830-
dc.description.abstractThe relative distribution of sensitizer drugs in the prostate and its contiguous organs is of importance in the treatment of localized prostatic cancer with photodynamic therapy. Using the primate model, whose prostate is both morphologically and physiologically homologous with its human counterpart, the distribution of hematoporphyrin derivative (HpD) amongst organs of urological interest was determined. Hematoporphyrin derivative levels were comparatively low in both caudal and cranial prostatic lobes (0.93-1.77 micrograms/g) and were similar to those in rectum, urethra and the skin. The reticuloendothelial organs, liver, spleen and also the kidney accumulated the highest quantities of porphyrin (4.76-9.8 micrograms/g, liver > spleen > kidney). Despite a high avidity of prostatic tissue for zinc, a zinc-metalloporphyrin (Zn-HpD) did not concentrate selectively in the prostate. The results are of clinical value in view of the homology between the primate and the human.en
dc.language.isoenen
dc.subjectHaematoporphyrin Derivativeen
dc.subject.meshAging-
dc.subject.meshAnimals-
dc.subject.meshBiological Transport-
dc.subject.meshCallithrix-
dc.subject.meshHematoporphyrin Derivative-
dc.subject.meshMale-
dc.subject.meshMetalloporphyrins-
dc.subject.meshMolecular Structure-
dc.subject.meshOrgan Specificity-
dc.subject.meshProstate-
dc.subject.meshTissue Distribution-
dc.titleThe uptake of porphyrin and zinc-metalloporphyrin by the primate prostate.en
dc.typeArticleen
dc.contributor.departmentUniversity Department of Urology, University Hospital of South Manchester, West Didsbury, U.K.en
dc.identifier.journalPhotochemistry and Photobiologyen
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