The dose-fractionation sensitivity of the kidney; assessment of viable tubule cross-sections at 19 months after X irradiation.

2.50
Hdl Handle:
http://hdl.handle.net/10541/100405
Title:
The dose-fractionation sensitivity of the kidney; assessment of viable tubule cross-sections at 19 months after X irradiation.
Authors:
Jen, Yee-Min; Hendry, Jolyon H
Abstract:
The formation of viable tubule cross-sections was assessed in histological sections of murine kidneys at 19 months after fractionated bilateral X-ray doses with 12 h intervals between fractions. The data were analysed using the linear-quadratic model which provides values of alpha and beta characterizing the slope of the dose-response curve, and the ratio of alpha and beta indicative of the sparing effect of dose fractionation. The tubule data were characterized by alpha = 0.057 +/- 0.009 Gy-1, beta = 0.011 +/- 0.001 Gy-2, alpha/beta = 5.0 +/- 0.9 Gy. Also, the number of cells (per focus region of the nephron) calculated as being capable of producing a viable focus was 2.5 +/- 0.5, which was confirmed using a separate two-dose approach (2.1 +/- 0.3). Together with other data, of the order of 1000 regenerative cells per nephron (10(4) total cells) can be deduced. The values of the fractionation sensitivity parameters are similar to values measured previously for cells taken from irradiated kidneys up to a year after irradiation and forming colonies in primary culture, and also similar to values assessed using various functional measures of kidney injury.
Affiliation:
Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, UK.
Citation:
The dose-fractionation sensitivity of the kidney; assessment of viable tubule cross-sections at 19 months after X irradiation. 1993, 66 (783):241-4 Br J Radiol
Journal:
British Journal of Radiology
Issue Date:
Mar-1993
URI:
http://hdl.handle.net/10541/100405
DOI:
10.1259/0007-1285-66-783-241
PubMed ID:
8472117
Type:
Article
Language:
en
ISSN:
0007-1285
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorJen, Yee-Minen
dc.contributor.authorHendry, Jolyon Hen
dc.date.accessioned2010-06-07T10:58:47Z-
dc.date.available2010-06-07T10:58:47Z-
dc.date.issued1993-03-
dc.identifier.citationThe dose-fractionation sensitivity of the kidney; assessment of viable tubule cross-sections at 19 months after X irradiation. 1993, 66 (783):241-4 Br J Radiolen
dc.identifier.issn0007-1285-
dc.identifier.pmid8472117-
dc.identifier.doi10.1259/0007-1285-66-783-241-
dc.identifier.urihttp://hdl.handle.net/10541/100405-
dc.description.abstractThe formation of viable tubule cross-sections was assessed in histological sections of murine kidneys at 19 months after fractionated bilateral X-ray doses with 12 h intervals between fractions. The data were analysed using the linear-quadratic model which provides values of alpha and beta characterizing the slope of the dose-response curve, and the ratio of alpha and beta indicative of the sparing effect of dose fractionation. The tubule data were characterized by alpha = 0.057 +/- 0.009 Gy-1, beta = 0.011 +/- 0.001 Gy-2, alpha/beta = 5.0 +/- 0.9 Gy. Also, the number of cells (per focus region of the nephron) calculated as being capable of producing a viable focus was 2.5 +/- 0.5, which was confirmed using a separate two-dose approach (2.1 +/- 0.3). Together with other data, of the order of 1000 regenerative cells per nephron (10(4) total cells) can be deduced. The values of the fractionation sensitivity parameters are similar to values measured previously for cells taken from irradiated kidneys up to a year after irradiation and forming colonies in primary culture, and also similar to values assessed using various functional measures of kidney injury.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshCell Count-
dc.subject.meshCell Survival-
dc.subject.meshDose-Response Relationship, Radiation-
dc.subject.meshKidney-
dc.subject.meshKidney Glomerulus-
dc.subject.meshKidney Tubules-
dc.subject.meshMale-
dc.subject.meshMice-
dc.subject.meshMice, Inbred Strains-
dc.subject.meshOrgan Size-
dc.subject.meshRadiation Injuries, Experimental-
dc.subject.meshTime Factors-
dc.titleThe dose-fractionation sensitivity of the kidney; assessment of viable tubule cross-sections at 19 months after X irradiation.en
dc.typeArticleen
dc.contributor.departmentDepartment of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, UK.en
dc.identifier.journalBritish Journal of Radiologyen

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