2.50
Hdl Handle:
http://hdl.handle.net/10541/100385
Title:
Cytogenetic studies of workers exposed to styrene: a review.
Authors:
Scott, David
Abstract:
In 17 of 50 cytogenetic studies (on chromosomal aberrations, micronucleus formation and sister chromatid exchange) in peripheral blood lymphocytes from a total of 667 workers in industries in which there is exposure to styrene, significant increases in the frequency of chromosomal damage have been reported when compared with unexposed controls. The positive or negative outcome of these studies is, however, unrelated to the extent of exposure to styrene. Furthermore, in the 17 investigations in which positive results were found, there is no convincing evidence of a positive dose-response relationship, in spite of the wide ranges of exposure and different methods of measurement. There are also serious discrepancies between findings on the chromosomal damaging effects of styrene in human lymphocytes in vitro and the types of damage reported in exposed workers. The findings are not consistent with the interpretation that styrene is responsible for the observed effects in workers. Several other chemicals identified in the environment of styrene workers have been reported to induce chromosomal damage in vitro and/or in vivo.
Affiliation:
Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, United Kingdom.
Citation:
Cytogenetic studies of workers exposed to styrene: a review. 1993 (127):275-86 IARC Sci. Publ.
Journal:
IARC Scientific Publications
Issue Date:
1993
URI:
http://hdl.handle.net/10541/100385
PubMed ID:
8070874
Type:
Article
Language:
en
ISSN:
0300-5038
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorScott, Daviden
dc.date.accessioned2010-06-07T10:46:27Z-
dc.date.available2010-06-07T10:46:27Z-
dc.date.issued1993-
dc.identifier.citationCytogenetic studies of workers exposed to styrene: a review. 1993 (127):275-86 IARC Sci. Publ.en
dc.identifier.issn0300-5038-
dc.identifier.pmid8070874-
dc.identifier.urihttp://hdl.handle.net/10541/100385-
dc.description.abstractIn 17 of 50 cytogenetic studies (on chromosomal aberrations, micronucleus formation and sister chromatid exchange) in peripheral blood lymphocytes from a total of 667 workers in industries in which there is exposure to styrene, significant increases in the frequency of chromosomal damage have been reported when compared with unexposed controls. The positive or negative outcome of these studies is, however, unrelated to the extent of exposure to styrene. Furthermore, in the 17 investigations in which positive results were found, there is no convincing evidence of a positive dose-response relationship, in spite of the wide ranges of exposure and different methods of measurement. There are also serious discrepancies between findings on the chromosomal damaging effects of styrene in human lymphocytes in vitro and the types of damage reported in exposed workers. The findings are not consistent with the interpretation that styrene is responsible for the observed effects in workers. Several other chemicals identified in the environment of styrene workers have been reported to induce chromosomal damage in vitro and/or in vivo.en
dc.language.isoenen
dc.subject.meshChromosome Aberrations-
dc.subject.meshChromosomes-
dc.subject.meshDose-Response Relationship, Drug-
dc.subject.meshHumans-
dc.subject.meshMicronucleus Tests-
dc.subject.meshOccupational Exposure-
dc.subject.meshSister Chromatid Exchange-
dc.subject.meshStyrene-
dc.subject.meshStyrenes-
dc.titleCytogenetic studies of workers exposed to styrene: a review.en
dc.typeArticleen
dc.contributor.departmentDepartment of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, United Kingdom.en
dc.identifier.journalIARC Scientific Publicationsen
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