Bioactivity and molecular modelling of diphenylsulfides and diphenylselenides.

2.50
Hdl Handle:
http://hdl.handle.net/10541/100235
Title:
Bioactivity and molecular modelling of diphenylsulfides and diphenylselenides.
Authors:
Woods, Julie A; Hadfield, John A; McGown, Alan T; Fox, Brian W
Abstract:
Bis(2-bromo-4,5-dimethoxyphenyl)sulfide (5) and bis(2-bromo-4,5-dimethoxyphenyl) selenide (7) have been shown to block cells in the G2/M phase of the cell cycle, whereas the debromo (4,6) equivalents do not. The biobromoselenide (7) is cytotoxic to tumour cells in vitro and has been shown to increase the mitotic index of treated cells. These biological effects are consistent with disruption of the mitotic apparatus. This agent does not inhibit microtubule assembly in vitro, but does bind to tubulin. Molecular modelling of these structures indicates that their spatial and electronic structures may make an important contribution to the biological activity.
Affiliation:
CRC Department of Experimental Chemotherapy, Pateson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.
Citation:
Bioactivity and molecular modelling of diphenylsulfides and diphenylselenides. 1993, 1 (5):333-40 Bioorg. Med. Chem.
Journal:
Bioorganic & Medicinal Chemistry
Issue Date:
Nov-1993
URI:
http://hdl.handle.net/10541/100235
DOI:
10.1016/S0968-0896(00)82139-2
PubMed ID:
8081863
Type:
Article
Language:
en
ISSN:
0968-0896
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorWoods, Julie Aen
dc.contributor.authorHadfield, John Aen
dc.contributor.authorMcGown, Alan Ten
dc.contributor.authorFox, Brian Wen
dc.date.accessioned2010-06-03T15:10:33Z-
dc.date.available2010-06-03T15:10:33Z-
dc.date.issued1993-11-
dc.identifier.citationBioactivity and molecular modelling of diphenylsulfides and diphenylselenides. 1993, 1 (5):333-40 Bioorg. Med. Chem.en
dc.identifier.issn0968-0896-
dc.identifier.pmid8081863-
dc.identifier.doi10.1016/S0968-0896(00)82139-2-
dc.identifier.urihttp://hdl.handle.net/10541/100235-
dc.description.abstractBis(2-bromo-4,5-dimethoxyphenyl)sulfide (5) and bis(2-bromo-4,5-dimethoxyphenyl) selenide (7) have been shown to block cells in the G2/M phase of the cell cycle, whereas the debromo (4,6) equivalents do not. The biobromoselenide (7) is cytotoxic to tumour cells in vitro and has been shown to increase the mitotic index of treated cells. These biological effects are consistent with disruption of the mitotic apparatus. This agent does not inhibit microtubule assembly in vitro, but does bind to tubulin. Molecular modelling of these structures indicates that their spatial and electronic structures may make an important contribution to the biological activity.en
dc.language.isoenen
dc.subjectLeukaemia P388en
dc.subjectOvarian Canceren
dc.subjectCultured Tumour Cellsen
dc.subject.meshAnimals-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshLeukemia P388-
dc.subject.meshMice-
dc.subject.meshModels, Molecular-
dc.subject.meshMolecular Structure-
dc.subject.meshOvarian Neoplasms-
dc.subject.meshSelenium Compounds-
dc.subject.meshStructure-Activity Relationship-
dc.subject.meshSulfides-
dc.subject.meshThermodynamics-
dc.subject.meshTubulin-
dc.subject.meshTumor Cells, Cultured-
dc.titleBioactivity and molecular modelling of diphenylsulfides and diphenylselenides.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Experimental Chemotherapy, Pateson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalBioorganic & Medicinal Chemistryen

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