Lack of association of HLA polymorphisms with human papillomavirus-related cervical cancer.

2.50
Hdl Handle:
http://hdl.handle.net/10541/100228
Title:
Lack of association of HLA polymorphisms with human papillomavirus-related cervical cancer.
Authors:
Glew, Susan S; Duggan-Keen, Margaret F; Ghosh, Anna K; Ivinson, A; Sinnott, P; Davidson, J; Dyer, P A; Stern, Peter L
Abstract:
An association of HLA-DQ3 with SCC of the cervix has been reported by researchers in Germany and Norway. This article documents a similar-sized study with patients and controls from northwest England. We report in detail on serologically determined HLA polymorphism in SCC patients with respect to HPV 16 infection, MHC class II expression within the tumor, serologic response to HPV, and other relevant clinical variables. We have also extended our studies to include DNA-based analysis using PCR and SSO probes for HLA-DQ. No significant association of any HLA-A, -B, -C, -DR, or -DQ antigen with SCC patients was found. While a possible explanation of the differences among studies could be a reflection of disease heterogeneity, the several tumor and clinical factors examined do not account for the observed differences from previous reports. Further studies are needed for a greater understanding of the interaction of HPV and HLA type in the development of cervical neoplasia.
Affiliation:
Department of Immunology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, England.
Citation:
Lack of association of HLA polymorphisms with human papillomavirus-related cervical cancer. 1993, 37 (3):157-64 Hum. Immunol.
Journal:
Human Immunology
Issue Date:
Jul-1993
URI:
http://hdl.handle.net/10541/100228
DOI:
10.1016/0198-8859(93)90181-Y
PubMed ID:
8244779
Type:
Article
Language:
en
ISSN:
0198-8859
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorGlew, Susan Sen
dc.contributor.authorDuggan-Keen, Margaret Fen
dc.contributor.authorGhosh, Anna Ken
dc.contributor.authorIvinson, Aen
dc.contributor.authorSinnott, Pen
dc.contributor.authorDavidson, Jen
dc.contributor.authorDyer, P Aen
dc.contributor.authorStern, Peter Len
dc.date.accessioned2010-06-03T14:26:55Z-
dc.date.available2010-06-03T14:26:55Z-
dc.date.issued1993-07-
dc.identifier.citationLack of association of HLA polymorphisms with human papillomavirus-related cervical cancer. 1993, 37 (3):157-64 Hum. Immunol.en
dc.identifier.issn0198-8859-
dc.identifier.pmid8244779-
dc.identifier.doi10.1016/0198-8859(93)90181-Y-
dc.identifier.urihttp://hdl.handle.net/10541/100228-
dc.description.abstractAn association of HLA-DQ3 with SCC of the cervix has been reported by researchers in Germany and Norway. This article documents a similar-sized study with patients and controls from northwest England. We report in detail on serologically determined HLA polymorphism in SCC patients with respect to HPV 16 infection, MHC class II expression within the tumor, serologic response to HPV, and other relevant clinical variables. We have also extended our studies to include DNA-based analysis using PCR and SSO probes for HLA-DQ. No significant association of any HLA-A, -B, -C, -DR, or -DQ antigen with SCC patients was found. While a possible explanation of the differences among studies could be a reflection of disease heterogeneity, the several tumor and clinical factors examined do not account for the observed differences from previous reports. Further studies are needed for a greater understanding of the interaction of HPV and HLA type in the development of cervical neoplasia.en
dc.language.isoenen
dc.subjectTumour Virus Infectionsen
dc.subjectUterine Cervical Canceren
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshAlleles-
dc.subject.meshCarcinoma, Squamous Cell-
dc.subject.meshDNA, Viral-
dc.subject.meshFemale-
dc.subject.meshHLA Antigens-
dc.subject.meshHLA-DQ Antigens-
dc.subject.meshHumans-
dc.subject.meshMiddle Aged-
dc.subject.meshPapillomaviridae-
dc.subject.meshPapillomavirus Infections-
dc.subject.meshPolymerase Chain Reaction-
dc.subject.meshPolymorphism, Genetic-
dc.subject.meshTumor Virus Infections-
dc.subject.meshUterine Cervical Neoplasms-
dc.titleLack of association of HLA polymorphisms with human papillomavirus-related cervical cancer.en
dc.typeArticleen
dc.contributor.departmentDepartment of Immunology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, England.en
dc.identifier.journalHuman Immunologyen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.