Intrinsic radiosensitivity and prediction of patient response to radiotherapy for carcinoma of the cervix.

2.50
Hdl Handle:
http://hdl.handle.net/10541/100222
Title:
Intrinsic radiosensitivity and prediction of patient response to radiotherapy for carcinoma of the cervix.
Authors:
West, Catharine M L; Davidson, Susan E; Roberts, Stephen A; Hunter, Robin D
Abstract:
The intrinsic radiosensitivity of cervical carcinoma has been measured using a soft agar clonogenic assay. All patients received radical radiotherapy alone with a minimum of 2 years post-treatment follow-up. Only women with stage I, II and III disease were included in the analysis. Values for cell surviving fraction at 2 Gy (SF2) were obtained for 88 tumours with an assay success rate of 73%. The 53 patients alive and well at the time of analysis had tumours with a mean SF2 that was significantly lower than the value from the 22 patients with locoregional failure (P < 0.01). Patients with radioresistant tumours (SF2 > 0.40, the median) had a significantly lower 3 year survival level than those with sensitive tumours (SF2 < or = 0.40) (P = 0.002). Also the frequency of local recurrence was higher (P = 0.001) whether these were central (P = 0.009) or peripheral (P = 0.046). Cell surviving fraction at 3.5 Gy was obtained for 46 tumours and the 3 year patient survival rate was significantly higher for those with SF3.5 values less than the median (P = 0.043). There was, however, no difference in the level of local recurrence (P = 0.24). The ability to grow in culture was not associated with significantly poorer patient survival (P = 0.56) or failure to control the primary disease (P = 0.17). While high colony forming efficiencies were associated with an increased rate of local recurrence (P = 0.029) they did not predict for overall patient survival (P = 0.32). These data suggest that, for cervical carcinoma treated with radical radiotherapy, intrinsic radiosensitivity is important in determining treatment outcome.
Affiliation:
Cancer Research Campaign Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Christie Hospital (NHS Trust), Manchester, UK.
Citation:
Intrinsic radiosensitivity and prediction of patient response to radiotherapy for carcinoma of the cervix. 1993, 68 (4):819-23 Br. J. Cancer
Journal:
British Journal of Cancer
Issue Date:
Oct-1993
URI:
http://hdl.handle.net/10541/100222
PubMed ID:
8398714
Type:
Article
Language:
en
ISSN:
0007-0920
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorWest, Catharine M Len
dc.contributor.authorDavidson, Susan Een
dc.contributor.authorRoberts, Stephen Aen
dc.contributor.authorHunter, Robin Den
dc.date.accessioned2010-06-03T11:50:29Z-
dc.date.available2010-06-03T11:50:29Z-
dc.date.issued1993-10-
dc.identifier.citationIntrinsic radiosensitivity and prediction of patient response to radiotherapy for carcinoma of the cervix. 1993, 68 (4):819-23 Br. J. Canceren
dc.identifier.issn0007-0920-
dc.identifier.pmid8398714-
dc.identifier.urihttp://hdl.handle.net/10541/100222-
dc.description.abstractThe intrinsic radiosensitivity of cervical carcinoma has been measured using a soft agar clonogenic assay. All patients received radical radiotherapy alone with a minimum of 2 years post-treatment follow-up. Only women with stage I, II and III disease were included in the analysis. Values for cell surviving fraction at 2 Gy (SF2) were obtained for 88 tumours with an assay success rate of 73%. The 53 patients alive and well at the time of analysis had tumours with a mean SF2 that was significantly lower than the value from the 22 patients with locoregional failure (P < 0.01). Patients with radioresistant tumours (SF2 > 0.40, the median) had a significantly lower 3 year survival level than those with sensitive tumours (SF2 < or = 0.40) (P = 0.002). Also the frequency of local recurrence was higher (P = 0.001) whether these were central (P = 0.009) or peripheral (P = 0.046). Cell surviving fraction at 3.5 Gy was obtained for 46 tumours and the 3 year patient survival rate was significantly higher for those with SF3.5 values less than the median (P = 0.043). There was, however, no difference in the level of local recurrence (P = 0.24). The ability to grow in culture was not associated with significantly poorer patient survival (P = 0.56) or failure to control the primary disease (P = 0.17). While high colony forming efficiencies were associated with an increased rate of local recurrence (P = 0.029) they did not predict for overall patient survival (P = 0.32). These data suggest that, for cervical carcinoma treated with radical radiotherapy, intrinsic radiosensitivity is important in determining treatment outcome.en
dc.language.isoenen
dc.subjectCancer Recurrenceen
dc.subjectCancer Stagingen
dc.subjectTumour Stem Cell Assayen
dc.subjectUterine Cervical Canceren
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasm Recurrence, Local-
dc.subject.meshNeoplasm Staging-
dc.subject.meshPrognosis-
dc.subject.meshRadiation Tolerance-
dc.subject.meshRadiotherapy Dosage-
dc.subject.meshTreatment Outcome-
dc.subject.meshTumor Stem Cell Assay-
dc.subject.meshUterine Cervical Neoplasms-
dc.titleIntrinsic radiosensitivity and prediction of patient response to radiotherapy for carcinoma of the cervix.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Christie Hospital (NHS Trust), Manchester, UK.en
dc.identifier.journalBritish Journal of Canceren

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