Expression of the Epstein-Barr virus latent membrane protein in nasopharyngeal carcinoma biopsy specimens.

2.50
Hdl Handle:
http://hdl.handle.net/10541/100086
Title:
Expression of the Epstein-Barr virus latent membrane protein in nasopharyngeal carcinoma biopsy specimens.
Authors:
Stewart, James P; Arrand, John R
Abstract:
It has been known for some time that the Epstein-Barr virus (EBV) is associated with nasopharyngeal carcinoma (NPC). The tumor cells are known to harbor EBV in a latent state. Latently-infected B cells that have become growth transformed by EBV in vitro express some 10 antigens, two of which (Epstein-Barr nuclear antigen 2 [EBNA2] and the latent membrane protein [LMP]) are associated with cellular transformation. We evaluated the expression of these two EBV antigens in NPC by probing tissue sections with monoclonal antibodies. We found that EBNA2 was not expressed and that LMP was expressed in seven of nine biopsy specimens. It is therefore postulated that either there are subsets of NPC or that LMP may be involved only in certain stages of tumor formation.
Affiliation:
Department of Molecular Biology, Paterson Institute for Cancer Research, Christie CRC Cancer Centre, Manchester, UK.
Citation:
Expression of the Epstein-Barr virus latent membrane protein in nasopharyngeal carcinoma biopsy specimens. 1993, 24 (3):239-42 Hum. Pathol.
Journal:
Human Pathology
Issue Date:
Mar-1993
URI:
http://hdl.handle.net/10541/100086
DOI:
10.1016/0046-8177(93)90032-C
PubMed ID:
8384158
Type:
Article
Language:
en
ISSN:
0046-8177
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorStewart, James Pen
dc.contributor.authorArrand, John Ren
dc.date.accessioned2010-06-01T15:20:35Z-
dc.date.available2010-06-01T15:20:35Z-
dc.date.issued1993-03-
dc.identifier.citationExpression of the Epstein-Barr virus latent membrane protein in nasopharyngeal carcinoma biopsy specimens. 1993, 24 (3):239-42 Hum. Pathol.en
dc.identifier.issn0046-8177-
dc.identifier.pmid8384158-
dc.identifier.doi10.1016/0046-8177(93)90032-C-
dc.identifier.urihttp://hdl.handle.net/10541/100086-
dc.description.abstractIt has been known for some time that the Epstein-Barr virus (EBV) is associated with nasopharyngeal carcinoma (NPC). The tumor cells are known to harbor EBV in a latent state. Latently-infected B cells that have become growth transformed by EBV in vitro express some 10 antigens, two of which (Epstein-Barr nuclear antigen 2 [EBNA2] and the latent membrane protein [LMP]) are associated with cellular transformation. We evaluated the expression of these two EBV antigens in NPC by probing tissue sections with monoclonal antibodies. We found that EBNA2 was not expressed and that LMP was expressed in seven of nine biopsy specimens. It is therefore postulated that either there are subsets of NPC or that LMP may be involved only in certain stages of tumor formation.en
dc.language.isoenen
dc.subjectNasopharyngeal Canceren
dc.subject.meshAntibodies, Monoclonal-
dc.subject.meshAntigens, Viral-
dc.subject.meshBiopsy-
dc.subject.meshCell Transformation, Neoplastic-
dc.subject.meshChina-
dc.subject.meshDNA-Binding Proteins-
dc.subject.meshEpstein-Barr Virus Nuclear Antigens-
dc.subject.meshFluorescent Antibody Technique-
dc.subject.meshGene Expression Regulation, Neoplastic-
dc.subject.meshHerpesvirus 4, Human-
dc.subject.meshHumans-
dc.subject.meshNasopharyngeal Neoplasms-
dc.subject.meshViral Matrix Proteins-
dc.titleExpression of the Epstein-Barr virus latent membrane protein in nasopharyngeal carcinoma biopsy specimens.en
dc.typeArticleen
dc.contributor.departmentDepartment of Molecular Biology, Paterson Institute for Cancer Research, Christie CRC Cancer Centre, Manchester, UK.en
dc.identifier.journalHuman Pathologyen
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