Expression of Epstein-Barr virus latent membrane protein influences self-renewal and differentiation in a multipotential murine haemopoietic 'stem cell' line.

2.50
Hdl Handle:
http://hdl.handle.net/10541/100082
Title:
Expression of Epstein-Barr virus latent membrane protein influences self-renewal and differentiation in a multipotential murine haemopoietic 'stem cell' line.
Authors:
Fairbairn, Leslie J; Stewart, J Philip; Hampson, Ian N; Arrand, John R; Dexter, T Michael
Abstract:
The product encoded by the latent membrane protein (LMP) gene of Epstein-Barr virus (EBV) has been implicated as a transforming protein by a number of studies. We have examined the effects of LMP expression in FDCP-mix cells, a growth factor-dependent multipotential murine 'stem cell' line. Our studies show that LMP reduces the generation of clonogenic cells and leads to the production of cells expressing a marker (lysozyme M) characteristic of mature monocytes and macrophages. Furthermore, cells expressing LMP are compromised in their ability to produce mature neutrophils. These data suggest that expression of LMP in primitive cells can modulate their self-renewal and differentiation potential and provide evidence in support of the suggestion that EBV may be involved in some of the maturation defects of haemopoiesis.
Affiliation:
Cancer Research Campaign Department of Experimental Haematology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, U.K.
Citation:
Expression of Epstein-Barr virus latent membrane protein influences self-renewal and differentiation in a multipotential murine haemopoietic 'stem cell' line. 1993, 74 ( Pt 2):247-54 J. Gen. Virol.
Journal:
The Journal of General Virology
Issue Date:
Feb-1993
URI:
http://hdl.handle.net/10541/100082
PubMed ID:
8381464
Type:
Article
Language:
en
ISSN:
0022-1317
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorFairbairn, Leslie Jen
dc.contributor.authorStewart, J Philipen
dc.contributor.authorHampson, Ian Nen
dc.contributor.authorArrand, John Ren
dc.contributor.authorDexter, T Michaelen
dc.date.accessioned2010-06-01T15:10:59Z-
dc.date.available2010-06-01T15:10:59Z-
dc.date.issued1993-02-
dc.identifier.citationExpression of Epstein-Barr virus latent membrane protein influences self-renewal and differentiation in a multipotential murine haemopoietic 'stem cell' line. 1993, 74 ( Pt 2):247-54 J. Gen. Virol.en
dc.identifier.issn0022-1317-
dc.identifier.pmid8381464-
dc.identifier.urihttp://hdl.handle.net/10541/100082-
dc.description.abstractThe product encoded by the latent membrane protein (LMP) gene of Epstein-Barr virus (EBV) has been implicated as a transforming protein by a number of studies. We have examined the effects of LMP expression in FDCP-mix cells, a growth factor-dependent multipotential murine 'stem cell' line. Our studies show that LMP reduces the generation of clonogenic cells and leads to the production of cells expressing a marker (lysozyme M) characteristic of mature monocytes and macrophages. Furthermore, cells expressing LMP are compromised in their ability to produce mature neutrophils. These data suggest that expression of LMP in primitive cells can modulate their self-renewal and differentiation potential and provide evidence in support of the suggestion that EBV may be involved in some of the maturation defects of haemopoiesis.en
dc.language.isoenen
dc.subjectHaematopoietic Stem Cellsen
dc.subject.meshAnimals-
dc.subject.meshAntigens, Viral-
dc.subject.meshCell Differentiation-
dc.subject.meshCell Line, Transformed-
dc.subject.meshCell Transformation, Viral-
dc.subject.meshHematopoietic Stem Cells-
dc.subject.meshHerpesvirus 4, Human-
dc.subject.meshMembrane Proteins-
dc.subject.meshPhenotype-
dc.subject.meshViral Matrix Proteins-
dc.titleExpression of Epstein-Barr virus latent membrane protein influences self-renewal and differentiation in a multipotential murine haemopoietic 'stem cell' line.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Department of Experimental Haematology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, U.K.en
dc.identifier.journalThe Journal of General Virologyen

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