2.50
Hdl Handle:
http://hdl.handle.net/10541/100068
Title:
A linkage study in seven breast cancer families.
Authors:
Teare, M Dawn; Santibanez-Koref, Mauro F; Wallace, S A; White, Gavin R M; Evans, D Gareth R; Burnell, Liza D; Harris, Martin; Howell, Anthony ( 0000-0002-3879-5991 ) ; Birch, Jillian M
Abstract:
Seven breast cancer families are examined for evidence of linkage to a site in the region of 17q12-q21, by using five markers. The families constitute a subset of a larger series of familial breast cancer; the seven families were selected because constitutional DNA was available on informative members, either from clinical samples or extracted from paraffin blocks. Two-point lod scores are reported. The maximum lod score, 0.8824, is obtained with marker NM23 at theta = 0. This is clearly not significant in itself; however, when taken in context with evidence from existing reports, it provides support for linkage to this region.
Affiliation:
Cancer Research Campaign Pediatric and Familial Cancer Research Group, Christie Hospital, Manchester, England.
Citation:
A linkage study in seven breast cancer families. 1993, 52 (4):786-8 Am. J. Hum. Genet.
Journal:
American Journal of Human Genetics
Issue Date:
Apr-1993
URI:
http://hdl.handle.net/10541/100068
PubMed ID:
8460644
Type:
Article
Language:
en
ISSN:
0002-9297
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorTeare, M Dawnen
dc.contributor.authorSantibanez-Koref, Mauro Fen
dc.contributor.authorWallace, S Aen
dc.contributor.authorWhite, Gavin R Men
dc.contributor.authorEvans, D Gareth Ren
dc.contributor.authorBurnell, Liza Den
dc.contributor.authorHarris, Martinen
dc.contributor.authorHowell, Anthonyen
dc.contributor.authorBirch, Jillian Men
dc.date.accessioned2010-06-01T11:25:53Z-
dc.date.available2010-06-01T11:25:53Z-
dc.date.issued1993-04-
dc.identifier.citationA linkage study in seven breast cancer families. 1993, 52 (4):786-8 Am. J. Hum. Genet.en
dc.identifier.issn0002-9297-
dc.identifier.pmid8460644-
dc.identifier.urihttp://hdl.handle.net/10541/100068-
dc.description.abstractSeven breast cancer families are examined for evidence of linkage to a site in the region of 17q12-q21, by using five markers. The families constitute a subset of a larger series of familial breast cancer; the seven families were selected because constitutional DNA was available on informative members, either from clinical samples or extracted from paraffin blocks. Two-point lod scores are reported. The maximum lod score, 0.8824, is obtained with marker NM23 at theta = 0. This is clearly not significant in itself; however, when taken in context with evidence from existing reports, it provides support for linkage to this region.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectHereditary Cancerous Syndromesen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshBreast Neoplasms-
dc.subject.meshChromosome Mapping-
dc.subject.meshChromosomes, Human, Pair 17-
dc.subject.meshFamily Health-
dc.subject.meshFemale-
dc.subject.meshGenetic Markers-
dc.subject.meshHumans-
dc.subject.meshLinkage (Genetics)-
dc.subject.meshLod Score-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplastic Syndromes, Hereditary-
dc.subject.meshPedigree-
dc.subject.meshProto-Oncogenes-
dc.titleA linkage study in seven breast cancer families.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Pediatric and Familial Cancer Research Group, Christie Hospital, Manchester, England.en
dc.identifier.journalAmerican Journal of Human Geneticsen

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