Influence of growth factors and substrates on differentiation of haemopoietic stem cells.

2.50
Hdl Handle:
http://hdl.handle.net/10541/100049
Title:
Influence of growth factors and substrates on differentiation of haemopoietic stem cells.
Authors:
Whetton, Anthony D; Dexter, T Michael
Abstract:
During the last few years there has been major progress in our understanding of the mechanisms underlying the regulation of haemopoietic stem cell proliferation and development. In the past 12 months, advances have been made in identifying how growth factor receptor expression is regulated in primitive haemopoietic cells, in determining the transcription factors that are associated with development, and in recognizing some of the specific molecular interactions that occur between the bone marrow stromal cells and the haemopoietic progenitor cells. These and previous studies clearly demonstrate that the environment can influence the survival, the proliferation and the differentiation of haemopoietic cells at every stage of development.
Affiliation:
Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.
Citation:
Influence of growth factors and substrates on differentiation of haemopoietic stem cells. 1993, 5 (6):1044-9 Curr. Opin. Cell Biol.
Journal:
Current Opinion in Cell Biology
Issue Date:
Dec-1993
URI:
http://hdl.handle.net/10541/100049
DOI:
10.1016/0955-0674(93)90090-D
PubMed ID:
8129942
Type:
Article
Language:
en
ISSN:
0955-0674
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorWhetton, Anthony Den
dc.contributor.authorDexter, T Michaelen
dc.date.accessioned2010-06-01T16:27:48Z-
dc.date.available2010-06-01T16:27:48Z-
dc.date.issued1993-12-
dc.identifier.citationInfluence of growth factors and substrates on differentiation of haemopoietic stem cells. 1993, 5 (6):1044-9 Curr. Opin. Cell Biol.en
dc.identifier.issn0955-0674-
dc.identifier.pmid8129942-
dc.identifier.doi10.1016/0955-0674(93)90090-D-
dc.identifier.urihttp://hdl.handle.net/10541/100049-
dc.description.abstractDuring the last few years there has been major progress in our understanding of the mechanisms underlying the regulation of haemopoietic stem cell proliferation and development. In the past 12 months, advances have been made in identifying how growth factor receptor expression is regulated in primitive haemopoietic cells, in determining the transcription factors that are associated with development, and in recognizing some of the specific molecular interactions that occur between the bone marrow stromal cells and the haemopoietic progenitor cells. These and previous studies clearly demonstrate that the environment can influence the survival, the proliferation and the differentiation of haemopoietic cells at every stage of development.en
dc.language.isoenen
dc.subjectHaematopoiesisen
dc.subjectHaemotopoietic Stem Cellsen
dc.subjectHaematopoietic Cell Growth Factorsen
dc.subject.meshAnimals-
dc.subject.meshApoptosis-
dc.subject.meshBone Marrow Cells-
dc.subject.meshCell Differentiation-
dc.subject.meshCells, Cultured-
dc.subject.meshConnective Tissue Cells-
dc.subject.meshCulture Media-
dc.subject.meshGene Transfer Techniques-
dc.subject.meshGrowth Inhibitors-
dc.subject.meshHematopoiesis-
dc.subject.meshHematopoietic Cell Growth Factors-
dc.subject.meshHematopoietic Stem Cells-
dc.subject.meshMice-
dc.subject.meshReceptors, Cell Surface-
dc.titleInfluence of growth factors and substrates on differentiation of haemopoietic stem cells.en
dc.typeArticleen
dc.contributor.departmentPaterson Institute for Cancer Research, Christie Hospital, Manchester, UK.en
dc.identifier.journalCurrent Opinion in Cell Biologyen

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